Shrunken FDA Advisory Committee Is Unanimous: Leqembi Works
The panel was persuaded of the antibody’s clinical efficacy and overall favorable benefit/risk ratio, although it had questions about risk in certain subgroups.
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Multiomic Analysis Shows Lysosomes Need Retromer to Stay Healthy
In VSP35 knockout cells, surface proteins get trapped in endolysosomes. They swell with undigested proteins and APP, then spew their contents outside the cell.
A Failing Sleep Neuropeptide Hypes Up Hippocampus
In amyloidosis mice, decline of the hypothalamic melanin-concentrating hormone system jacks up neuronal activity, and contributes to sleep problems.
Do Activated Glia Contribute to Long COVID?
A tiny PET study saw gliosis in putamen and striatum of some with persistent depression after COVID; larger health registry studies find scant evidence.
Multi-Organ MRI Unveils Myriad Connections Between Heart and Brain
Dozens of structural features of the heart correlated with measures of regional volume, integrity of white-matter tracts, and functional connectivity within the brain.
CMS Sticks to Its Guns on Amyloid Immunotherapy Coverage
The agency reiterated its earlier decision that traditionally approved amyloid antibodies will be covered if physicians enter data into a patient registry.
In Amyloid Cascade, Do Reactive Astrocytes Bridge Plaques and Tangles?
Among cognitively healthy people, amyloid load tracked with blood p-tau181 and tangles only in those with high blood GFAP.
When Autophagy Stops, Microglia Sour into Senescence
Backed up, the cells never transitioned into a disease-associated state, shirking their plaque compaction and synapse protection duties.
Nature Aging Issue Focuses on Dementia Research
Three reviews, two perspectives, and four comments discuss recent advances and opportunities for dementia research.
Abnormal Tau Slips into Synapses Long Before Tangles Form
More evidence that presynaptic tau may spread from neuron to neuron.
Does “Good” Cholesterol Increase Your Risk of Alzheimer’s?
Mendelian randomization identified HDL cholesterol and systolic blood pressure as modifiable risk factors.
Amyloid Jungle: Plaque Fibrils Mesh With All Manner of Vesicles, Membranes
Arranged in bundles and lattices within a plaque, Aβ42 fibrils were intermixed with extracellular vesicles of different shapes and sizes. Their origin remains unknown.
Brain Within a Brain? Nested Organoids a New Way to Study Human Microglia
Transplanting a human cerebral organoid containing microglia into a mouse brain allows the cells to thrive in something close to their natural environment.
Hi-Res Spatial Proteomics Uncovers Aspects of Alzheimer’s Disease Pathology
Multiplex analyses spy a new microglial subtype that surrounds Aβ plaques, and a type of neuron resilient to neurofibrillary tangles.
Paper Alert: Those Fibrils Floating in Brain Fluid Are Toxic
They can be neutralized by lecanemab, an anti-amyloid antibody designed to mop up Aβ protofibrils.
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