TMEM106B Variants Regulate Gene Modules, TDP-43 Pathology
A GWAS of co-expression modules identifies a haplotype that disrupts lysosomes and myelination. ApoE4 and Aβ regulate the same module.
ALL NEWS
213 RESULTS
Sort By:
- Most Recent
- Most Commented
Disadvantaged Neighborhoods Raise Odds of Alzheimer’s
People who lived in impoverished neighborhoods in their last year of life had greater odds of having died with AD neuropathology.
GnomAD: Stunning Variation Seen in Largest Collection of Human Genomes
In seven papers, researchers presented a dazzling set of findings gleaned from 125,748 exomes and 15,708 genomes housed in a new database. Tidbits emerge on tau, LRRK2, and other proteins implicated in neurodegeneration.
Low-Dose BACE Inhibitors Might Preserve Synaptic Function
In cell culture, slashing Aβ production by more than half harmed neuronal signaling, but a smaller cut maintained it.
New Astrocyte Marker Allows Purification from Mixed Cultures
Researchers identify a way to isolate human astrocytes generated from induced pluripotent stem cells. And astrocytes stand out in FTD-prone brain areas.
Without SORL1, Endosomes Swell in Neurons but not Microglia
Induced neurons lacking the Alzheimer’s risk gene can’t properly recycle APP.
Shiny SEQUIN: New Technique Counts Synapses Over Large Brain Volumes
Using a form of confocal microscopy and automated software, the method allows researchers to rapidly identify functional synapses within brain structures.
Simulating Tangle Spread Along Axons, Scientists Predict Tau PET Patterns
The modeling approach reinforces the idea that tau pathology propagates through the brain’s physical architecture, including neuronal networks.
Molecular Transport Vehicle Shuttles Therapies into Brain
Built to cross the blood-brain barrier, the vehicle delivers therapeutic antibodies, enzymes, and potentially small molecules such as oligonucleotides.
Umbilical Cord With Presenilin Mutation Births New Cell Model of Familial AD
Umbilical cord stem cells from presenilin 1 E280A carriers, once differentiated into cholinergic-like neurons, pumped out Aβ42 and accumulated phosphorylated tau and apoptotic markers.
Paper Alert: CryoEM Structures of α-Synuclein Published
In stark contrast to Aβ and tau fibrils, α-synuclein fibrils are asymmetric, comprising two different protofibrils.
In Colombian Alzheimer’s Kindred, Blood NfL Climbs 22 Years Before Symptoms
The plasma biomarker neurofilament light was able to distinguish individual mutation carriers from noncarriers three years prior to onset.
Massive Proteomics Studies Peg Glial Metabolism, Myelination, to AD
Separately, cerebrovascular disease drove an uptick in neurofilament light in the brain, indicating neurodegeneration.
The Air We Breathe—How Might Pollution Hurt the Brain?
Chemicals and particulates may slip across the blood-brain barrier or travel up olfactory nerves to directly affect brain cells. What are the consequences for cognition?
Air Pollution and Dementia—Through Hazy Data, Links Emerge
Growing evidence suggests exposure to air pollution increases risk of brain damage and dementia. More definitive research is needed.
Current Filters
- Date Range : May 2020 to May 2021 x