Once branded as a difficult target, β-secretase has become the crowd favorite. But might pharma have to cool its jets?
As new substrates and functions for BACE continue to emerge, scientists worry about adverse effects of blocking the protease.
Researchers at a meeting on BACE shared concerns that blocking the protease in adults might have unexpected consequences.
Researchers at BACE meeting explore how trafficking and degradation of the protease relate to amyloid pathology in AD.