The center collects, processes, stores, and distributes samples, including longitudinal samples, from its research participants. Collections are taken from donors in their 40s to late 90s in a limited geographic area. Nigel Cairns leads the neuropathology core for DIAN samples; the fluid biomarker core leader Ann Fagan, (314) 362-3453, fagana@neuro.wustl.edu, handles CNS tissue samples. The center receives fasted cerebrospinal fluid and matched plasma samples; genetics core Alison Goate collects DNA from blood and non-fasted plasma. Phenotypes collected include Alzheimer's disease, family history of Alzheimer's, cognitively normal, healthy normal, dementia with Lewy bodies, frontotemporal dementia, tauopathy, and Parkinson's disease. Samples taken include whole brain, hemisphere, and spinal cord, and fasted CSF. Fixed, frozen, block, and stained tissues are available to researchers after review by an external committee.