Antibody

β-Actin (AC-15)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: EM, IB, IC, IH
Source: Sigma Aldrich
Cat# A1978
References:
(many, unspecified formulation)
Burré J, 2010
Machiya, 2010
O'Connor, 2008
Ohsawa, 2008
Maier, 2008
Luo, 2007
Matheu, 2007
Formulation: aqueous solution, purified, PBS, azide
Reactivity:
Reacts in: Bovine, Cat, Dog, Chicken, Carp, Sheep, Pig, Human, Guinea Pig, Mouse, Rat, Drosophila
and Hirudo medicinalis

Immunogen/Epitope

immunogen = slightly modified β-cytoplasmic actin N-terminal peptide, Ac-D D D I A A L V I D N G S G L, KLH conj.

Specificity

detects 42 kDa beta-actin

Comments / Questions

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References

Paper Citations

  1. . Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science. 2010 Sep 24;329(5999):1663-7. PubMed.
  2. . Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner. J Biol Chem. 2010 Dec 24;285(52):40732-44. PubMed.
  3. . Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26;60(6):988-1009. PubMed.
  4. . Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci. 2008 Jun 11;28(24):6239-49. PubMed.
  5. . Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci. 2008 Jun 18;28(25):6333-41. PubMed.
  6. . Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6. PubMed.
  7. . Delayed ageing through damage protection by the Arf/p53 pathway. Nature. 2007 Jul 19;448(7151):375-9. PubMed.

Further Reading

No Available Further Reading