Antibody

α-Tubulin (B-5-1-2)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Sigma Aldrich
Cat# T6074
References:
Granic, 2010
Muresan, 2009
D'Angelo, 2009
Seeburg, 2008
Planel, 2008
Roberson, 2007
(all, unspecified formulation)
Formulation: liquid, purified IgG, PBS, azide
Reactivity:
Reacts in: Bovine, Chicken, Sea Urchin, Chlamydomonas, Human, Monkey, Mouse, Rat

Immunogen/Epitope

immunogen = Sarkosyl-resistant filaments from sea urchin

Specificity

recognizes an epitope located at the C-terminal end of alpha-tubulin

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References

Paper Citations

  1. Granic A, Padmanabhan J, Norden M, Potter H. Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP. Mol Biol Cell. 2010 Feb 15;21(4):511-20. PubMed.
  2. Muresan V, Varvel NH, Lamb BT, Muresan Z. The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites. J Neurosci. 2009 Mar 18;29(11):3565-78. PubMed.
  3. D'Angelo MA, Raices M, Panowski SH, Hetzer MW. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell. 2009 Jan 23;136(2):284-95. PubMed.
  4. Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DT, Sheng M. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Neuron. 2008 May 22;58(4):571-83. PubMed.
  5. Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci. 2008 Nov 26;28(48):12798-807. PubMed.
  6. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007 May 4;316(5825):750-4. PubMed.

Further Reading

No Available Further Reading