Antibody

Tau (T46)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Zymed/ Invitrogen
Cat# 13-6400
References:
Kosmidis, 2010
Paquet, 2009
Rao, 2008
Guo, 2006
Formulation: liquid, purified, ascites, PBS, azide
Reactivity:
Reacts in: Bovine, Human

Immunogen/Epitope

immunogen = bovine tau (epitope near the C-terminal region, 404-441 aa of human tau)

Specificity

Both phos. and non phos. forms of tau, and all 7 isoforms., human NFTs, and some cross-reactivity with MAP2

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References

Paper Citations

  1. Kosmidis S, Grammenoudi S, Papanikolopoulou K, Skoulakis EM. Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila. J Neurosci. 2010 Jan 13;30(2):464-77. PubMed.
  2. Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C. A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest. 2009 May;119(5):1382-95. PubMed.
  3. Rao MV, Mohan PS, Peterhoff CM, Yang DS, Schmidt SD, Stavrides PH, Campbell J, Chen Y, Jiang Y, Paskevich PA, Cataldo AM, Haroutunian V, Nixon RA. Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. J Neurosci. 2008 Nov 19;28(47):12241-54. PubMed.
  4. Guo JP, Arai T, Miklossy J, McGeer PL. Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1953-8. PubMed.

Further Reading

No Available Further Reading