Antibody

Tau pS422

Clonality: polyclonal
Host: Rabbit
Methods: WB
Source: Biosource Invitrogen
Cat# 44-764G
References:
van Eersel, 2010
Alonso, 2010
Sontag, 2008
Planel, 2008
Yuzawa, 2008
Formulation: purified Ig, PBS, BSA, azide, glycerol, unconjugated
Reactivity:
Reacts in: Human
expect mouse, rat

Immunogen/Epitope

human tau-derived peptide that is phosphorylated at serine 422

Specificity

tau phosphorylated at serine 422

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References

Paper Citations

  1. . Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13888-93. PubMed.
  2. . Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem. 2010 Oct 1;285(40):30851-60. PubMed.
  3. . Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation. J Neurosci. 2008 Nov 5;28(45):11477-87. PubMed.
  4. . Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci. 2008 Nov 26;28(48):12798-807. PubMed.
  5. . A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol. 2008 Aug;4(8):483-90. PubMed.

Further Reading

No Available Further Reading