Antibody

Tau, phospho 181P

Tools

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Clonality: kit
Host: Unknown Host
Source: Innogenetics
cat# INNOTEST® PHOSPHO-TAU(181P)
datasheet online at website
References:
Compta, 2010
Fagan, 2009
Buerger, 2009
Visser, 2009
Mattsson, 2009
Shaw, 2009
Laske, 2008
Fagan, 2007
Roberson, 2007
Formulation: solid-phase ELISA, uses monoclonal HT7 for capture, AT270 biotinylated for incubation, streptavidin; working range: 25 to 150 pg/mL
Reactivity:
Reacts in: Human

Immunogen/Epitope

 

Specificity

specific for tau phosphorylated at threonine 181, antigen in cerebrospinal fluid (CSF)

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References

Paper Citations

  1. . High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal β-amyloid in Parkinson disease. Neurosci Lett. 2011 Jan 7;487(2):169-73. PubMed.
  2. . Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease. EMBO Molecular Medicine. 2009 Nov 1;1(8-9):371-380.
  3. . Validation of Alzheimer's disease CSF and plasma biological markers: the multicentre reliability study of the pilot European Alzheimer's Disease Neuroimaging Initiative (E-ADNI). Exp Gerontol. 2009 Sep;44(9):579-85. PubMed.
  4. . Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. Lancet Neurol. 2009 Jul;8(7):619-27. PubMed.
  5. . CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA. 2009 Jul 22;302(4):385-93. PubMed.
  6. . Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Abeta 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia. Eur Arch Psychiatry Clin Neurosci. 2009 Mar;259(2):80-5. PubMed.
  7. . Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch Neurol. 2007 Mar;64(3):343-9. Epub 2007 Jan 8 PubMed.
  8. . Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007 May 4;316(5825):750-4. PubMed.

Further Reading

No Available Further Reading