Antibody

Tau (AT8)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1κ
Methods: ELISA, IH, WB
Source: Autogen Bioclear
cat# 90206
References:
Chu, 2009
Anderson, 2008
Houlden, 2008
Rockenstein, 2007
Van Uden, 2002
Dou, 2003
supplied by Innogenetics
Formulation: liquid, PBS, sterile filtered, affinity purified
Reactivity:
Reacts in: Human

Immunogen/Epitope

partially purified human tau, aa. around phosphorylated Ser 202

Specificity

phosphorylated PHF tau at Ser 202; no cross with normal tau

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References

Paper Citations

  1. . A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2097-103. PubMed.
  2. . Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis. Brain. 2008 Jul;131(Pt 7):1736-48. PubMed.
  3. . Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nat Genet. 2007 Dec;39(12):1434-6. PubMed.
  4. . Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci. 2007 Feb 21;27(8):1981-91. PubMed.
  5. . Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein. J Neurosci. 2002 Nov 1;22(21):9298-304. PubMed.
  6. . Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):721-6. PubMed.

Further Reading

No Available Further Reading