Antibody

α-Synuclein

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Clonality: monoclonal
Host: Mouse
Source: α-Synuclein Syn303
(Virginia Lee, University of Pennsylvania, CNDR, Philadelphia, PA)
References:
Reference:
Tsika, 2010
Giasson, 2002
Reactivity:
Reacts in: Human
reference:<br />Giasson BI. Duda JE. Murray IV. ... Lee V.M.-Y. Science., 290:985-989, 2000

Immunogen/Epitope

immunogen = oxidized α-synuclein

Specificity

preferentially recognizes oxidized and/or nitrated α-syn in human inclusions; recognizes oligomeric forms of α-syn in human brain tissue with α-syn aggregates

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References

Paper Citations

  1. Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, Giasson BI, Krainc D, Ischiropoulos H, Mazzulli JR. Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J Neurosci. 2010 Mar 3;30(9):3409-18. PubMed.
  2. Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 2002 May 16;34(4):521-33. PubMed.

External Citations

  1. Virginia Lee
  2. CNDR

Further Reading

No Available Further Reading