Clonality: monoclonal
Host: Mouse
Isotype: IgG₁,κ
Source: Chemicon and Upstate are Millipore
Cat# MAB5258-20UG
or MAB5258-50UG
References:
Chung, E, 2010
Cherny, 2001
Formulation: purified Ig, PBS, azide
Reactivity:
Reacts in: Avian (various), Fish (various), Bovine, Human, Mouse, Rat

Immunogen/Epitope

immunogen = vesicular fraction of bovine brain

Specificity

reacts with synaptophysin in presynaptic vesicles of cerebral andspinal neurons, neuromuscular endplates and with the retina

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References

Paper Citations

1. Chung E, Ji Y, Sun Y, Kascsak RJ, Kascsak RB, Mehta PD, Strittmatter SM, Wisniewski T. Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. BMC Neurosci. 2010;11:130. PubMed.
2. Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 2001 Jun;30(3):665-76. PubMed.

Further Reading

No Available Further Reading