Antibody

α-II-Spectrin /Fodrin (AA6)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Chemicon and Upstate are Millipore
Cat# MAB1622
References:
Rao, 2008
Trinchese, 2008
Formulation: liquid, PBS,BSA, azide
Reactivity:
Reacts in: Rabbit, Chicken, Pig, Human, Guinea Pig, Mouse, Rat

Immunogen/Epitope

Immunogen = purified Chicken red blood cell membranes

Specificity

240 kDa α-II-spectrin/fodrin of all mammalian nonerythroid cells and chicken alpha-spectrin. Antibody will all recognize caspase (150kDa, 120kDa) and calpain cleavage (150kDa) products of alpha fodrin

Note

not IH(P)

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References

Paper Citations

  1. Rao MV, Mohan PS, Peterhoff CM, Yang DS, Schmidt SD, Stavrides PH, Campbell J, Chen Y, Jiang Y, Paskevich PA, Cataldo AM, Haroutunian V, Nixon RA. Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. J Neurosci. 2008 Nov 19;28(47):12241-54. PubMed.
  2. Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest. 2008 Aug;118(8):2796-807. PubMed.

Further Reading

No Available Further Reading