Antibody

ERK1/2 p44/42 phos Thr202/Tyr204 (E10)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Cell Signaling
Cat# 9106
References:
Zempel H, 2010
Nagahara, 2009
Townsend, 2007
Dorsey, 2006
Formulation: liquid, BSA, HEPES, NaCl, glycerol, azide.<br />See also Cat# 4374, Alexa Fluor® 488 Conjugate;<br />Cat# 4375, Alexa Fluor® 647 Conjugate;
Reactivity:
Reacts in: Bovine, Mink, Zebra fish, Pig, Human, Monkey, Hamster, Mouse, Rat, Drosophila

Immunogen/Epitope

Immunogen = synthetic phospho-peptide corresp. to residues surrounding Thr202/Tyr204 of human p44 MAP kinase

Specificity

Detects endogenous levels pf p44/42 MAP kinase (ERK1/2) dually phosphorylated at Thr202 and tyr204. Does not cross-react with the corresp. phospho-residues of SAPK/JNK or p38 MAP kinase

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References

Paper Citations

  1. Zempel H, Thies E, Mandelkow E, Mandelkow EM. Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci. 2010 Sep 8;30(36):11938-50. PubMed.
  2. Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski MH. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Mar;15(3):331-7. PubMed.
  3. Townsend M, Mehta T, Selkoe DJ. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem. 2007 Nov 16;282(46):33305-12. PubMed.
  4. Dorsey SG, Renn CL, Carim-Todd L, Barrick CA, Bambrick L, Krueger BK, Ward CW, Tessarollo L. In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron. 2006 Jul 6;51(1):21-8. PubMed.

Further Reading

No Available Further Reading