Antibody

ERK1/2 p44/42 phos Thr202/Tyr204 (E10)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: FC, IC, IF, IP, WB
Source: Cell Signaling
Cat# 9106
References:
Zempel H, 2010
Nagahara, 2009
Townsend, 2007
Dorsey, 2006
Formulation: liquid, BSA, HEPES, NaCl, glycerol, azide.<br />See also Cat# 4374, Alexa Fluor® 488 Conjugate;<br />Cat# 4375, Alexa Fluor® 647 Conjugate;
Reactivity:
Reacts in: Bovine, Mink, Zebra fish, Pig, Human, Monkey, Hamster, Mouse, Rat, Drosophila

Immunogen/Epitope

Immunogen = synthetic phospho-peptide corresp. to residues surrounding Thr202/Tyr204 of human p44 MAP kinase

Specificity

Detects endogenous levels pf p44/42 MAP kinase (ERK1/2) dually phosphorylated at Thr202 and tyr204. Does not cross-react with the corresp. phospho-residues of SAPK/JNK or p38 MAP kinase

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References

Paper Citations

  1. . Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci. 2010 Sep 8;30(36):11938-50. PubMed.
  2. . Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Mar;15(3):331-7. PubMed.
  3. . Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem. 2007 Nov 16;282(46):33305-12. PubMed.
  4. . In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron. 2006 Jul 6;51(1):21-8. PubMed.

Further Reading

No Available Further Reading