Antibody

APP (mAbP2-1)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: A B R - Thermo Scientific
Cat# OMA1-03132
Reference:
Tampellini, 2009
Tampellini, 2007
Formulation: purified IgG, PBS
Reactivity:
Reacts in: Primate (various), Human

Immunogen/Epitope

immunogen = N-terminal 100 amino acids from protease nexin-II (PN-II), which is the secreted form of human APP

Specificity

N-terminus of APP

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References

Paper Citations

  1. Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo-Zarate E, Ma T, Zheng R, Lu B, Nanus DM, Lin MT, Gouras GK. Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations. J Neurosci. 2009 Aug 5;29(31):9704-13. PubMed.
  2. Tampellini D, Magrané J, Takahashi RH, Li F, Lin MT, Almeida CG, Gouras GK. Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. J Biol Chem. 2007 Jun 29;282(26):18895-906. PubMed.

Further Reading