Clonality: polyclonal
Host: Rabbit
Isotype: IgG
Source: Calbiochem EMD Biosciences
cat# 171610
References:
Varvel, 2009
Qin, 2006
Green, 2006
Formulation: liquid, undiluted serum, no preserve
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = synthetic peptide (K M Q Q N G Y E N P T Y K F F E Q M Q N) at C-terminal region (aa 751-770) of human APP, conj. to KLH

Specificity

detects C-terminal products CTFα (~9 kDa), CTFβ (~11 kDa) and CTFγ (~6 kDa) and full length APP

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References

Paper Citations

1. Varvel NH, Bhaskar K, Patil AR, Pimplikar SW, Herrup K, Lamb BT. Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci. 2008 Oct 22;28(43):10786-93. PubMed.
2. Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006 Aug 4;281(31):21745-54. PubMed.
3. Green KN, Billings LM, Roozendaal B, McGaugh JL, Laferla FM. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J Neurosci. 2006 Aug 30;26(35):9047-56. PubMed.

Further Reading