Antibody

Amyloid β [x-42] and Aβ [x-40]

Tools

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Clonality: kit
Host: Unknown Host
Source: Innogenetics
cat# INNO-BIA
blood ß-amyloid kit
Leaflet
References:
Fagan, 2009
Lambert, 2009
Formulation: well standardized multiparameter bead-based immunoassay for the simultaneous quantification of human ß-amyloid in plasma using xMAP® (registered trademark of Luminex Corp)technology
Reactivity:
Reacts in: Human

Immunogen/Epitope

Uses 4G8 antibody;
4G8 selectively binds juxtamembrane EC domain, aa 17-24; (epitope lies within aa 18-22)

Specificity

reactive to Aβ; for simultaneous quantification of different forms of β-amyloid in blood, with check for matrix interference

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References

Paper Citations

  1. Fagan AM, Mintun MA, Shah AR, Aldea P, Roe CM, Mach RH, Marcus D, Morris JC, Holtzman DM. Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease. EMBO Molecular Medicine. 2009 Nov 1;1(8-9):371-380.
  2. Lambert JC, Schraen-Maschke S, Richard F, Fievet N, Rouaud O, Berr C, Dartigues JF, Tzourio C, Alpérovitch A, Buée L, Amouyel P. Association of plasma amyloid beta with risk of dementia: the prospective Three-City Study. Neurology. 2009 Sep 15;73(11):847-53. PubMed.

External Citations

  1. Leaflet

Further Reading

No Available Further Reading