Antibody

Actin (AC-40)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG2a
Source: Sigma Aldrich
Cat# A3853
References:
( Zempel H, 2010
Yuzawa, 2008
Cumming, 2007
all, unspecified formulation, see also Cat# 4700 )
Formulation: liquid, purified, PBS, azide
Reactivity:
Reacts in: Various species

Immunogen/Epitope

immunogen = synthetic actin CN-terminal peptide, Ser-Gly-Pro-Ser-Ile- Val-His-Arg-Lys-Cys-Phe, attached to a Multiple Antigen Peptide (MAP) backbone

Specificity

42 kDa actin; recognizes an epitope located on the C-terminal end of actin conserved in all actin isoforms

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References

Paper Citations

  1. Zempel H, Thies E, Mandelkow E, Mandelkow EM. Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci. 2010 Sep 8;30(36):11938-50. PubMed.
  2. Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol. 2008 Aug;4(8):483-90. PubMed.
  3. Cumming RC, Dargusch R, Fischer WH, Schubert D. Increase in expression levels and resistance to sulfhydryl oxidation of peroxiredoxin isoforms in amyloid beta-resistant nerve cells. J Biol Chem. 2007 Oct 19;282(42):30523-34. PubMed.

Further Reading

No Available Further Reading