Moving Alzheimer’s Diagnosis to Primary Care Could Ease Bottlenecks
A Rand report concludes that using blood-based biomarkers and cognitive tests in primary care would halve wait times for new disease-modifying therapies.
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A Rand report concludes that using blood-based biomarkers and cognitive tests in primary care would halve wait times for new disease-modifying therapies.
The software could improve prognosis, speed referrals, for people with MCI, the developer claims.
Using live imaging in mice, scientists found that tracers and immune cells move between brain and dura through gaps in the arachnoid mater around veins.
With newly available fluid biomarkers that detect α-synuclein pathology in the brain, researchers articulate ways to classify the disease based on its biology.
In mice, these Aβ fibrils avoid riling microglia and astrocytes. They also evade both PiB and lecanemab.
A large, unbiased study found 125 proteins in the CSF that tick up or down in early familial AD. A set of nine identified FAD mutation carriers better than did Aβ and tau.
A new, stem-cell-based method generated neural cultures that live long enough to suffer the consequences of TDP-43 dysregulation.
In more than 52,000 cognitively healthy people, elevated plasma GFAP or NfL more than doubled the risk the person would develop dementia over the next 14 years.
Eight adults who, as children, had received growth hormone from cadavers developed cognitive problems and/or AD-like pathology in midlife.
People receiving personalized Type 2 diabetes management were 28 percent less likely to develop dementia, and 15 percent less likely to get Alzheimer's.
In CD8+ T cells and monocytes, DNA was more accessible in people with AD and even more so in ApoE4 carriers.
£50 million in funding will expand trial access, increase recruitment, streamline study processes, and train staff over the next five years.
Methylated CAG-repeat RNAs and 14-3-3θ promote TDP-43 aggregation.
A new immunoassay detects N-terminal fragments of tau. They predict tangle accumulation, cortical atrophy, and cognitive decline.
Using different methods and studying different populations, two studies report similar trajectories of fluid and imaging biomarkers over a 20-year span of AD.