In Parkinson’s, Synuclein Fibrils Fold Differently Than in MSA
Synuclein fibrils from Parkinson’s disease, PD dementia, and dementia with Lewy bodies share the same protofilament structure. MSA fibrils are different.
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Tales of Traveling Tau: Is Transfer Between Neurons Normal?
Is transfer of tau from one neuron to the next a normal activity, hijacked by pathogenic protein in the case of tauopathies?
What Happens After Amyloid Plaque Removal? Who Benefits Most?
Clearance triggers improvement in downstream markers of inflammation and neurodegeneration—but not in those who started with high tangle burden. (Clue: women.)
Alzheimer's Association International Conference (AAIC)- 2023
Donanemab Data Anchors Upbeat AAIC Give BACE Inhibitors a Second Chance? CSF MTBR-tau-243 Tracks Tangles, Plummets in Response to Antibody Cohort LEADS Toward Better Understanding of Sporadic Early Onset AD Spying on α-Synuclein Inclusions: PET Tracers In
Alzheimer’s Early Detection Challenge Announced
The NIA invites scientists to submit data to create diverse, open datasets and design diagnostic algorithms for more accurate, early prediction of Alzheimer’s.
Brain Imaging: What Does it See in DLB?
In dementia with Lewy bodies, basic scans are used in routine diagnosis. Multimodal imaging and new PET tracers for affected neurotransmitters of pathological deposits in the brain and gut are entering research settings.
In Alzheimer Brain, Can Synaptic Pruning Be Good?
Provocative new data suggest that glial engulfment of synapses dampens network hyperexcitability early in disease. Key mediators: TREM2 and phosphatidylserine.
Plasma Proteomics Studies Link Genetic Variants to Phenotypes
A consortium of pharma companies mined data from 50,000 people in the U.K. Biobank to turn up thousands of new gene-protein connections.
TREM2 Cleavage Site Pinpointed: A Gateway to New Therapies?
Researchers identify where proteases snip the microglial receptor TREM2 to release its extracellular domain: exactly at the site of a rare AD risk variant.
Cutting (or Slippery?) Edge: Lipids in Neurodegeneration Science
At a conference on lipids in the brain, scientists reported how unsaturated fatty acids might worsen or ameliorate the effects of proteinopathies.
Cracking the Cholesterol-AD Code: Metabolites and Cell Type
A cholesterol metabolite magnifies pathology in a tauopathy mouse. Microglia need cholesterol to rein in amyloid. ApoE4 jams the fat's export from neuron to glia.
Can Flipping a Lipid Switch Protect the Brain?
At Leiden conference, scientists discussed how shifting cells toward “specialized pro-resolving mediators” could counter inflammation.
Border Surprise: Glia Limitans Astrocytes Sit on Brain Surface
A new study defined the location and expression profile of this astrocyte subtype, pegging the protein myocilin as a marker.
To Recruit for Diverse Alzheimer Trials, Go to the People
Most participants in AD research studies and trials are non-Hispanic whites. At a conference in St. Louis, scientists discussed strategies to include diverse populations.
From St. Louis to Boston, Scientists Grapple with Ethnoracial Divide in AD Biomarkers
Across several studies, black/African Americans and Hispanic or Latino people had lower amyloid positivity rates than whites. Scientists are studying why.
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