Besides accumulating in Lewy bodies, p-S129syn binds its synaptic vesicle protein partners better than does its unmodified counterpart.
The first study to survey the brain transcriptomes of people with NHD identified microglia and astrocytes in the midst of overzealous injury repair, and narrowing blood vessels.
Data from six countries showed an increase in prescriptions for antipsychotic drugs in 2020, with use remaining high in many countries ever since.
A new method reveals distinct synaptic states, as well as amyloidosis-associated changes not seen in nuclear transcriptomic data.
The FDA turned down Eli Lilly’s application based on insufficient safety data, with fewer than 100 people on the drug for one year.
A transferrin receptor binding domain helps transport the antibody across the blood-brain barrier. In the brain, it roused microglia and boosted glucose metabolism.
In one, the N-terminus was highly structured. In the other, the N-terminus was disordered, similar to Aβ peptides found in the brain parenchyma.
In fly tauopathy model, dsRNA triggers inflammation and neuron death. In Alzheimer’s, dsRNA accumulates in the brain.
Last year saw major advances in multi-omics analyses using human tissues, better animal models, deeper functional studies of gene variants, dissections of neuroimmune cell biology, and more.
Therapeutics research in the field ended on high hopes that lecanemab’s Phase 3 data would carry this anti-Aβ antibody to regulatory approval in country after country in 2023. This wave drew power from progress in biomarker research; but alas, much work remains to be done.
Sex and ApoE genotype influenced the function of the millions of microbes that colonize the mouse gut. Short-chain fatty acids appear to carry messages from bacteria to cytokine-producing cells.
The lymphatic-like membrane blankets blood vessels in the subarachnoid space and harbors immune cells.
Eisai’s anti-amyloid antibody got the nod via the accelerated approval pathway; the company is expected to apply for traditional approval within days.
Recent reports of three deaths in the lecanemab extension study suggest that blood thinners, lecanemab, and cerebral amyloid angiopathy could be a dangerous combination.
Courtesy of one changed amino acid, human microglia resist drugs that typically destroy them. The cells behave normally and replenish endogenous mouse microglia
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