At AAN, Sights Set on Antisense Therapies for Diseases of the Brain
Antisense oligonucleotides are raising hopes for tackling a wide range of brain disorders—is the enthusiasm warranted?
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American Academy of Neurology Annual Meeting 2018
As RNA Therapies Come of Age, Efficacy Remains Weak At AAN, Sights Set on Antisense Therapies for Diseases of the Brain Will RNA molecules that bump up or tamp down gene expression live up to their potential? Results from RNA-targeting therapies presented ...
As RNA Therapies Come of Age, Efficacy Remains Weak
At AAN, the latest data from Phase 3 trials and open-label extensions of RNA-targeting therapies reveal a bit of benefit, but no cure.
No REST for the Brainy: Human Evolution Linked to Diseases of Aging
Genetic adaptations that gave humans their smarts may promote diseases of aging, including cancer, Alzheimer’s, and Parkinson’s. One adaptation counteracted REST, a proposed protector against AD.
Bad Synergy—Together, Vascular Problems and Aβ Hasten Memory Slippage
High vascular risk scores and Aβ burden independently associate with cognitive decline, but combined, they speed things up.
U.S. Study Says Lithium in Tap Water Does Not Fend Off Dementia
Prior evidence for protective effect evaporates after adjustment for demographic differences in high- and low-lithium communities.
Cerebrovascular Disease: Does Tau Mediate Cognitive Decline?
PET study finds tau signal associated with markers of cerebrovascular disease and cognitive issues.
To Deliver Itself From Cell to Cell, Phospho-Tau Uses UPS
Not the brown trucks with the friendly delivery guys: UPS as in unconventional protein secretion pathway. Tau rides it to slink out of one cell, and, grabbing onto heparin sulfate proteoglycans, enter another.
Liver Tox Ends Janssen BACE Program
The company has halted all trials of atabecestat.
“Nanosweeper” Brushes Aβ into Cellular Dustbins
Engineered nanoparticles snatched extracellular Aβ, ferried it into cells, and switched on autophagy, clearing the peptide from the brains of mice. Would this work as a drug?
No, TDP-43 and FUS Are Not Actively Exported From the Nucleus
Contrary to previous findings, both proteins seem to escape via passive diffusion. This has implications for therapeutic strategies to keep them where they belong.
Oligodendrocytes Seem to Imprint Specific Alter Ego on α-Synuclein
Aggregates that form inside, or just pass through, oligodendrocytes take on the properties of the virulent strain that gives rise to multiple system atrophy.
Study Finds Sex Influences CSF Tau Levels in ApoE4 Carriers
ApoE4 raises CSF tau more in women than in men, suggesting sex may influence the risk of neurodegeneration, especially in amyloid-positive E4 carriers.
Cholesterol Greases the Aβ Aggregation Machine
Exposure to lipid membranes embedded with cholesterol accelerate Aβ fibril formation by up to 20-fold.
Do Mild Traumatic Brain Injuries Double the Risk of Dementia?
A large retrospective study in veterans finds that even brain injuries that cause no loss of consciousness come with a twofold higher risk of developing all-cause dementia.
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