Can BACE2 Protect Against Amyloidosis?
The protease suppresses Aβ in Down’s syndrome organoids.
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CryoEM of CBD Tau Suggests Another Unique Protofibril
Post-translational modifications differ from those in AD tau fibrils, and may dictate tau strains.
New Myelin Makes Memories, but Supply Wanes with Age
The creation of long-term memories requires a continual supply of myelin provided by newly formed oligodendrocytes. Alas, the generation of fresh oligodendrocytes diminishes with age, along with memory.
Paper Alert: Phase 3 Trial Data Published on Sleep Aid Suvorexant
FDA approves adding safety and efficacy data from an Alzheimer’s trial to the drug’s label.
Topline Result for First DIAN-TU Clinical Trial: Negative on Primary
DIAN, Roche, Lilly disclose that neither gantenerumab nor solanezumab slowed cognitive decline in the first-pass comparison of drug and placebo groups. Analyses are ongoing; dose may have been too low.
Multimodal Imaging of Neurodegenerative Diseases Links Pathology and Cellular Dysfunction
Synapse loss and mitochondrial stress, as seen by separate PET tracers, go hand-in-hand in Alzheimer’s, Parkinson’s, and frontotemporal dementia.
PET Tracer Detects Synapse Loss Across Alzheimer’s Brain
New research presented at the HAI conference also finds links between UCB-J uptake and plaques, tangles, and cognitive decline.
Human Amyloid Imaging 2020
PET Tracer Detects Synapse Loss Across Alzheimer’s Brain Multimodal Imaging of Neurodegenerative Diseases Links Pathology and Cellular Dysfunction As methodology improves, the new tracer UCB-J reliably flags synapse loss in Alzheimer’s cortex, reported ...
Toxic α-Synuclein: Egged on by ApoE4, Thwarted by ApoE2?
Quite independently of what it does to Aβ or tau, ApoE4 stokes α-synuclein pathology in mouse models. People with Lewy body dementia who carry ApoE4 had more phosphorylated synuclein in their brains, and their cognition declined faster.
A Central Role for Prion Protein in Neurodegeneration?
Researchers implicate PrP in the toxicity of Aβ, tau, and α-synuclein oligomers in several neurodegenerative diseases.
Paper Alert: Two ApoE2s Provide “Exceptional” Protection Against AD
Compared with people who carry two copies of ApoE3 or ApoE4, ApoE2 homozygotes had an 87 and 99.6 percent lower risk for AD, respectively.
Does Young-Onset Parkinson’s Arise in Lysosomes?
Poor lysosomal function in dopaminergic neurons derived from people with YOPD points to disease origin and potential therapies.
Soccer Heading Has Greater Impact on Memory in ApoE4 Carriers
Frequent heading weakened verbal memory in amateur soccer players, and more so in ApoE4 carriers.
Chaperone Stabilizer Fends Off Amyloid, Memory Loss in Mice
A small molecule binds the retromer complex, preventing Aβ accumulation, tau hyperphosphorylation, and their downstream consequences in mice.
In AD, Chaperones Congregate To Form a Therapeutic Target
Aberrant protein-protein interactions centered on HSP90 may contribute to Alzheimer’s disease. Can an inhibitor set things right?
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