Flortaucipir Imaging Distinguishes Alzheimer’s From Other Disorders
A large multicenter study confirms the tau PET ligand identifies AD at the dementia stage, but not so well at prodromal stages.
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In Conditional BACE1 Knockouts, Hippocampal Axons Compromised
Ablating BACE1 in adult mice spares them from most problems found in germline knockouts. However, axons extending from newborn hippocampal neurons still lose their way.
Does LRRK2 Sweep α-Synuclein from the Cell?
By promoting the exocytosis of cellular debris, the kinase may facilitate spread of α-synuclein aggregates.
Cognitive Deficits Worse with ALS Stage
Neuropsychological impairments are common in amyotrophic lateral sclerosis, even more so for people at late stages of disease.
Lifestyle Coaching Slows Cognitive Decline in African-Americans with MCI
A behavioral intervention slowed memory slippage and functional decline over two years.
Does Cognition Change With the Seasons?
In large cohorts, older people tested in summer and autumn scored higher on cognitive tests than people tested in winter and spring. Is a seasonal clock ticking in the background?
Model Morass? R47H Mutation Scuttles TREM2 Expression in Mice, Not People
A new finding questions the usefulness of some mouse models.
Exercise Pill? Pharmacological Mimics Boost Cognition in Lazy Mice
Treatments that promote neurogenesis and elevate BDNF act as exercise does to improve memory in mouse models of Alzheimer’s disease.
ALS Mutations Stiffen Profilin, Steer Protein Toward Aggregation
Computational models predict that ALS mutations tax the flexibility of profilin-1, weaken binding with key partners including actin, and boost the protein’s propensity to aggregate.
Tau Stymies Transport Through Neuron’s Nucleus
By yanking a nuclear protein out of its pore, phosphorylated tau makes nuclei leaky, disrupting the strictly controlled passage of proteins and setting tau up for aggregation.
Flortaucipir Meets Primary Endpoints in Phase 3 Autopsy Trial
PET tracer predicts tau pathology and AD, according to company press release.
Does Retinal Thinning Reflect Early Alzheimer’s?
Study links changes in the retina’s microvasculature to brain amyloid in cognitively normal adults.
Let ’Er RIP: ALS/FTD Variant Plus Aging Unleash Deadly Kinase
Loss-of-function mutations in TBK1 combined with age-related dearth of an analog spell trouble for motor neurons and the central nervous system.
Conformers Confirmed: Structure of Pick’s Tau Distinct from AD Tau
A molecular-level view of tau filaments from a person with Pick’s disease reveals that the protein folds up differently than it does in Alzheimer’s disease.
Tiny Passageways Connect Skull Bone Marrow to the Brain
Vascular microchannels linking the skull bone marrow to the dura mater supply the brain with neutrophils in response to stroke and inflammation.
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