Brain Conference Spotlights Transcriptomics, Therapeutic Strategies
New potential immunotherapies and insight into single-cell responses were highlights of a small meeting in Denmark.
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Neurogenesis Wanes in Alzheimer’s, Along With Cognition
Research on postmortem human brain strengthens the idea that an ebbing of neurogenesis may underlie cognitive decline.
Are Disease Mutations Lurking Within ‘Dark Regions’ of the Genome?
Thousands of stretches of the genome go undetected by standard short-read sequencing techniques. Unmasking these “dark regions” revealed a potential AD risk variant in the CR1 gene.
When it Comes to Alzheimer’s Disease, Do Human Microglia Even Give a DAM?
Using single-nuclei or cell sorting, three separate research groups sequenced RNA from human postmortem brains. They unveiled AD-associated gene-expression signatures, but disease-related transcriptomes from human microglia were quite different from those in mice.
American Academy of Neurology 2019 Annual Meeting
Antisense Oligonucleotides: Can They Take on ALS, SMA, Prions? American Academy of Neurology 2019 Annual Meeting ...
Antisense Oligonucleotides: Can They Take on ALS, SMA, Prions?
Data on ASOs, presented recently at the annual meeting of the American Academy of Neurology, depict RNA-based therapies as broadly on the rise in neurodegenerative diseases.
C9ORF72 Toxicity Tied to Mitochondria, Transcriptional Machinery
In a new, inducible mouse model, poly(GR) damages mitochondria, but its effect is reversible. In flies, turning off transcription of hexanucleotide expansion protects cells.
Paper Alert: VCAM1 Opens the Door to Brain Aging
Expression of VCAM1 on the endothelial cells that line the blood-brain barrier allowed aging factors in the plasma to exact their toll on the brain.
BACE Inhibitors: Postmortem on One, Live Updates on Two
Lanabecestat, elenbecestat, and umibecestat all showed data at the AD/PD conference in Lisbon. Learn what definitely doesn’t work and what might yet.
Plasticity Hums With Protein Synthesis on Both Sides of Synapse
Long recognized in dendrites, scientists now report that substantial synaptic proteome remodeling happens on the axonal side, too.
Gamma Waves Synchronized by Light: Good for Synapses, Memory?
More mouse data add to the argument that a flashing light sequence could potentially fight cognitive decline.
WHO Weighs in With Guidelines for Preventing Dementia
The global agency’s report recommends physical activity, a healthy diet, stopping alcohol abuse and smoking, and managing one’s weight, blood pressure, and diabetes.
Keep Your Enthusiasm? Scientists Process Brutal Trial Data
“We are learning” was the tenor of debate about the latest round of setbacks for anti-amyloid trials in symptomatic Alzheimer’s disease at a recent conference in Lisbon.
Forget Fibrils: Lewy Pathology Is More Lipid Than Protein
An electron microscopy study reveals a jumbled mess of membrane chunks and malfunctioning organelles, bound together by phosphorylated or truncated α-synuclein.
Do Immune Cells Promote the Spread of α-Synuclein Pathology?
At AD/PD 2019, scientists implicated both peripheral and central innate immunity in promoting propagation.
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