Shape-Shifting Prion Protein in Cytosol: Highly Toxic Yet Almost Invisible
Read about this new mechanism proposed to explain the pathogenesis of prion diseases. Featured in "In the Spotlight" on our homepage.
ALL NEWS
6410 RESULTS
Sort By:
- Most Recent
- Most Commented
Nicastrin Mutations Selectively Modulate Notch Processing
Worries over side effects of γ-secretase inhibitors due to their unwanted effect on Notch cleavage might ease a little with a report demonstrating that the two cleavage events may be regulated at least partly independently. Certain nicastrin mutations affect only Notch cleavage, not AβPP cleavage.
The Alzheimer's Vaccination Story, Continued
Two papers advance the drive to develop an Alzheimer's vaccine, one looking at the antibody response in some of the Elan trial participants, the other using sophisticated methods to analyze the epitope recognized by antibodies generated in response to Aβ42 immunization.
Promising Gene Therapy for Parkinson’s
Using gene therapy to boost production of the inhibitory neurotransmitter GABA has produced marked improvements in a rat model of Parkinson's....
α-synuclein—Less Is More?
In today's PNAS early edition, researchers report that transgenic mice devoid of the protein α-synuclein are resistant to MPTP, a neurotoxin that induces Parkinson-like symptoms....
PET Reduces Alzheimer Misdiagnosis
Can PET improve on the battery of tests that are already in use to diagnose Alzheimer's. A new study shows that imaging analysis decreases the number of false negatives by five percent and the number of false positives by more than 10 percent...
Ubiquitin Protease Implicated in Ataxia
A mutation in mice that causes ataxia, or muscle paralysis, has been identified as an insertion of 5.2 kb of DNA in the gene for ubiquitin-specific protease 14 (Usp14)....
Memantine Back On Sidelines In United States
Less than two weeks after announcing that memantine had shown significant benefit in a clinical trial of patients with moderate to severe Alzheimer's disease, Forest Laboratories announced that they have withdrawn their New Drug Application with the FDA...
More Evidence for Dynamic PolyQ Aggregates
Fluorescence imaging has become a powerful tool for measuring protein mobility and is particularly suited to probing the dynamics of protein-protein interactions in inclusion bodies....
Light Tricks
A trio of papers introduces new optical tricks for manipulating gene expression and activating fluorescent reporters...
Oxidative Stress Triggers Neuronal Cell-Cycle Reentry
Researchers from The Jackson Laboratory and Tufts University report that oxidative stress is linked to cell-cycle re-entry and neurodegeneration in a mouse expressing abnormally low levels of the apoptosis-inducing factor (Aif) gene...
Memantine Claimed to Augment Donepezil's Effects
Forest Laboratories, Inc., reported last week that patients with moderate to severe Alzheimer's disease taking memantine and donepezil had significant improvement over patients on donepezil alone on tests of cognitive and daily functioning...
Trials and Tribulations: Does ADAPT Have to Adapt?
Researchers working on NSAIDs as potential treatments for AD are discussing whether a large ongoing prevention trial of two such anti-inflammatories is testing the right drugs.
Aβ Mutations—What Do They Tell Us?
Convergent biochemical and genetic evidence indicate that the main component of Alzheimer's plaques, the amyloid β peptide (Aβ), plays an initiating role in a complex cascade that culminates in dementia and ultimately death (1,2).
All in the Family: Alois Alzheimer’s Second Patient Came from Extended Disease Pedigree
During his lifetime, Alois Alzheimer described five cases of the “characteristic sickness of the cerebral cortex” that his boss, the eminent psychiatrist Emil Kraepelin, later would name in honor of his late colleague. Now, neurologists in Alzheimer’s home state of Bavaria are investigating how these early patients’ family members fared. One patient, Johann F., turns out to have belonged to a large clan afflicted with an early-onset, heritable form of the disease. Many descendants still live in Bavaria, some in the U.S.
Current Filters
No filters selected