Cortical Biopsies Hint at Start of Alzheimer's 'Cellular Phase'
Layer 1 interneurons vanish. Layer 2/3 excitatory neurons become hyperactive, then fade. Microglia change state. Astrocytes react. No symptoms yet. Is this preclinical Alzheimer's?
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Brain Tissue From Living People with Amyloid Plaques Can Fire in a Dish
Scientists have established acute slice recordings from cerebral cortex biopsies. They find circuitry and basic function to be preserved. They also find changes in the presence of Alzheimer's pathology.
A Day's Work: Cortex Biopsy Comes Out. Shunt Goes In. Patient Goes Home.
Every week in a Finnish operating room, bits of human cortex get lifted from brains and straight into electrophysiology rigs. Other tissues go to diagnostic and research labs, or biobanks, for ADRD research. Read how it happens.
Fresh Brain Every Friday: Biopsies Transform Alzheimer's Science
In the Finnish city of Kuopio, surgeons and scientists have built a unique protocol. It improves life for people with hydrocephalus—and it banks cortical tissue rife with preclinical pathology and gene variants for Alzheimer's research.
Kuopio Hydrocephalus Shunt Biopsy Protocol
In the Finnish city of Kuopio, neurosurgeons collaborate with neurophysiologists and molecular and cellular biologists to make frontal cortex, dura, intraventricular CSF, skin, fat, and other tissue from hydrocephalus patients available for research purpo
Tau Propagation Surprise: It Might Travel Retrogradely
A new method for precisely localizing pathological tau in whole mouse brain finds that its spread follows network connections—but it seems to move up axons, not down.
Ridding Microglia of a MicroRNA Compacts Amyloid, Protects Synapses
In mice with amyloidosis, removal of miR-155 from microglia rendered the cells more receptive to IFN-γ stimulation, improving neuroprotection.
FDA Clears Roche’s CSF Aβ42/tTau Assay
The Elecsys-based assay could run on 100,000 fully automated diagnostic machines worldwide.
Treatment for Lysosomal Storage Disorder Lowers NfL
In a small open-label Phase 1/2 trial, Denali’s enzyme replacement therapy lowered neurofilament light in the cerebrospinal fluid by half and in serum by two-thirds.
Better Cell Model? Transdifferentiated Neurons Capture AD-Like Changes
New studies report that transdifferentiated neurons from AD patients retain signatures of aging. They also model lysosomal dysfunction, tau phosphorylation, and cell death.
Transcriptomics Confirm Vascular Changes in Alzheimer’s Brain
Cells of the neurovascular unit upregulate inflammation-related genes and stifle genes of the blood-brain barrier. The genes include 125 known to carry AD risk variants.
Does Taurine Deficiency Accelerate Aging in Mice, Monkeys?
Feeding taurine to mice and monkeys increased the lifespan of the former and reduced signs of aging in both.
Field Loses Another Prominent Neuropathologist, Donald Price, 87
Known for his work on animal models, APP processing, and the cholinergic system, Price founded one of the first Alzheimer’s Disease Research Centers.
Listen to Your Gut. It Might Signal Early Alzheimer’s Disease.
In cognitively unimpaired older adults, some gut bacteria correlated with plaques and tangles, but not neurodegeneration.
Field Says Farewell to Neuropathologist Yasuo Ihara, 78
A giant of basic science, Ihara biochemically characterized Aβ and tau deposits in AD brain, laying the groundwork for subsequent discoveries.
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