FDA Will Regulate Diagnostic Tests. Yes, Those for Alzheimer’s, Too.
Blood and other in vitro assays will need to meet the same standards as medical devices, including demonstrating diagnostic accuracy.
ALL NEWS
204 RESULTS
Sort By:
- Most Recent
- Most Commented
Do Two APOE4 Alleles Always Mean Alzheimer's?
By age 65, nearly all people who carry two copies of APOE4 harbor neuropathological or biomarker evidence of AD pathology.
Beyond Microglia—Alzheimer’s Gene PLCγ2 Acts on Synapses, Too.
In mice and cultured human neurons, PLCγ2 knockdown thinned out synapses and suppressed neuron firing. Rare loss-of-function PLCγ2 variants hike AD risk 10-fold.
More Evidence that Locus Coeruleus Demise Precedes Cortical Tangles
People who had a damaged locus coeruleus accumulated tangles in their medial temporal lobes over the next three years, and their cognition declined.
Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
Known for shuttling APP, the endosomal receptor latches on to tau. Knocking it down in glia reduced tau seeding. The N1358S risk variant ramped it up.
From Treadmills to Transcriptomes: Consortium Charts Molecular Responses to Exercise
First papers from MoTrPAC initiative report myriad responses to endurance training in multiple organs in rats, including the brain and heart.
In ADAD, Plaque Removal Improves Synaptic and Inflammatory Biomarkers
In the DIAN familial AD prevention trial, plaque-busting antibody gantenerumab, but not monomer-targeting solanezumab, nudged fluid markers toward normal.
Stirred by Tau, Neurons Amp Up Lipid Droplets in Glia
Tauopathy cranks up lipid synthesis in neurons, which slip the fats to microglia. Blocking AMP kinase greases this process.
APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
Amyloid precursor protein CTFs accumulate in lysosomes adjacent to endoplasmic reticulum. This disrupts calcium flow between the organelles.
Two Paths for TREM2-Positive Microglia: DAM or Senescence?
Scientists find the senescent subtype has a distinct protein signature, but little change in gene expression, causing it to be overlooked in transcriptomic studies.
Axons or Bust: To Reach Neuron Extremities, RNAs Hitch a Ride on Lysosomes
Lysosomes deliver a plethora of mRNA transcripts, including those encoding ribosomal subunits and mitochondrial proteins, to axonal terminals for translation.
Diabetes Drug Shows Promise for Parkinson’s Disease
In a small Phase 2 trial, the GLP-1 analogue lixisenatide stabilized motor abilities over one year in people with early PD.
Could New Alzheimer’s Marker p-Tau212 Rival p-Tau217?
In preliminary studies in five cohorts, the two markers have similar diagnostic accuracy, and stain tangles in postmortem brain equally well.
Tau Toggling Peptides: One Seeds Fibrils; the Other Dismantles Them
Two studies describe how small peptides that latch onto tau have an outsize impact on fibrillization of the protein. Both point to therapeutic strategies.
Rubbing Microglia the Right Way? At ADPD, Scientists Showcase New Strategies
Preclinical studies and early phase trials target microglial receptors CD33 and TREM2, and amyloid-stoking ASC specks.
Current Filters
- Date Range : May 2023 to May 2024 x