Mis-splicing events produce novel proteins that can be detected in the cerebrospinal fluid of ALS/FTD patients before their symptoms even start.
The protein binds to segments of tau prone to aggregate, preventing neurofibrillary tangles and neurodegeneration.
Twelve severe viral illnesses boosted risk up to 15 years after infection.
SORL1 may form polymers that bind and stabilize the retromer, facilitating the recycling of APP and other substrates.
p-S129syn better binds its synaptic vesicle protein partners than does plain α-synuclein.
The first study to survey the brain transcriptomes of people with NHD found microglia and astrocytes frantically repairing injury, and narrowing blood vessels.
Data from six countries showed prescriptions for antipsychotic drugs rose in 2020, and remain high.
A new method reveals distinct synaptic states, some tied to amyloidosis, that were not seen in prior nuclear transcriptomic data.
The FDA turned down Eli Lilly’s application based on insufficient safety data, with fewer than 100 people on the drug for one year.
A transferrin receptor binding domain helps transport the antibody across the blood-brain barrier. In the brain, it roused microglia and boosted glucose metabolism.
In one, the N-terminus was highly structured. In the other, the N-terminus was disordered, similar to Aβ peptides found in the brain parenchyma.
In fly tauopathy model, dsRNA triggers inflammation and neuron death. In Alzheimer’s, dsRNA accumulates in the brain.
Last year saw major advances in multi-omics analyses using human tissues, better animal models, deeper functional studies of gene variants, dissections of neuroimmune cell biology, and more.
Therapeutics research in the field ended on high hopes that lecanemab’s Phase 3 data would carry this anti-Aβ antibody to regulatory approval in country after country in 2023. This wave drew power from progress in biomarker research; but alas, much work remains to be done.
Sex and ApoE genotype influenced the function of the millions of microbes that colonize the mouse gut. Short-chain fatty acids appear to carry messages from bacteria to cytokine-producing cells.
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