PAPER Kempster PA, Bogetic Z, Secombei JW, Martin HD, Balazs ND, Wahlqvist ML

Motor effects of broad beans (Vicia faba) in Parkinson's disease: single dose studies.

Asia Pac J Clin Nutr. 1993 Jun;2(2):85-9. PubMed: 24352104

PAPER Muda K, Bertinetti D, Gesellchen F, Hermann JS, von Zweydorf F, Geerlof A, Jacob A, Ueffing M, Gloeckner CJ, Herberg FW

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E34-43. Epub 2013 Dec 18 PubMed: 24351927

PAPER Sáez-Francàs N, Hernández-Vara J, Corominas-Roso M, Alegre J, Jacas C, Casas M

Relationship between poor decision-making process and fatigue perception in Parkinson's disease patients.

J Neurol Sci. 2014 Feb 15;337(1-2):167-72. Epub 2013 Dec 7 PubMed: 24351900

PAPER Memedi M, Khan T, Grenholm P, Nyholm D, Westin J

Automatic and objective assessment of alternating tapping performance in Parkinson's disease.

Sensors (Basel). 2013 Dec 9;13(12):16965-84. PubMed: 24351667

PAPER Mast N, Li Y, Linger M, Clark M, Wiseman J, Pikuleva IA

Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice.

J Biol Chem. 2014 Feb 7;289(6):3529-38. Epub 2013 Dec 18 PubMed: 24352658

Maya Mitalipova

Whitehead Institute for Biomedical Research
Cambridge, United States

Richard Ransohoff on Beyond Neighborhood Watch—Microglia Nurture Synapses

COMMENT This paper reports a groundbreaking piece of work. The major new conceptual insight is that microglia play critical roles (as do all brain cells) in the development and maintenance of the CNS. One can no longer think of “resting” microglia because they’re

PAPER Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T

Layer V cortical neurons require microglial support for survival during postnatal development.

Nat Neurosci. 2013 May;16(5):543-51. Epub 2013 Mar 24 PubMed: 23525041

Beyond Neighborhood Watch—Microglia Nurture Synapses

RESEARCH NEWS 2013-12-20 Research News Besides patrolling the brain for tissue damage and other emergencies, microglia also help with routine maintenance, according to new research in the December 19 Cell. In adult mice engineered to lose microglia on demand, Wenbiao Gan, New Yor

PAPER Goldmann T, Wieghofer P, Müller PF, Wolf Y, Varol D, Yona S, Brendecke SM, Kierdorf K, Staszewski O, Datta M, Luedde T, Heikenwalder M, Jung S, Prinz M

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.

Nat Neurosci. 2013 Nov;16(11):1618-26. Epub 2013 Sep 29 PubMed: 24077561

PAPER Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain.

Nature. 2005 Dec 15;438(7070):1017-21. PubMed: 16355225

Concepcion Goldberg, Terry Goldberg on Averting a Late-life Crisis: Midlife ApoE2 Clears Plaques in Mice

COMMENT We read with interest Hudry and Hyman's comprehensive set of studies examining the effects of ApoE2 and E4 isoforms in transgenic mice. Our own recent work, now in press at Molecular Psychiatry and all in humans (ex vivo and in vivo), nicely compleme

Concepcion Goldberg

The Feinstein Institute for Medical Research
Manhasset, United States

Carlos Cruchaga on Effect of TMEM106B Polymorphism on Functional Network Connectivity in Asymptomatic GRN Mutation Carriers.

COMMENT In this paper, Premi et al. describe the effect of the TMEM106B risk variant on functional connectivity in progranulin gene (GRN) mutation carriers, more specifically among asymptomatic carriers. This study provides very valuable information about the ear

Risk Genes Influence Brain Connectivity in Preclinical FTD

RESEARCH NEWS 2013-12-20 Research News Previous studies indicated that polymorphisms in the TMEM106B gene exacerbate frontotemporal dementia caused by progranulin mutations, advancing disease onset by more than a decade. Now, new research strengthens the case for that synergy, an