PAPER Irving AJ, Harvey J
SEARCH RESULTS
330026 RESULTS
PAPER Wright JW, Kawas LH, Harding JW
A Role for the Brain RAS in Alzheimer's and Parkinson's Diseases.
Front Endocrinol (Lausanne). 2013 Oct 25;4:158. PubMed: 24298267Presenilin-2 (PSEN2)
ALZPEDIA Presenilin-2 (PSEN2) is one of two highly homologous presenilin genes expressed in vertebrates. Presenilin-1 (PSEN1) has been more extensively studied in Alzheimer’s research because fewer mutations in PSEN2 are known. Mutations in the presenilin genes ar
Presenilin-1 (PSEN1)
ALZPEDIA Presenilins were originally identified as the genes harboring mutations that cause autosomal-dominant Alzheimer’s disease. Such mutations occur in both presenilin-1 and its homolog presenilin-2, but the former are far more numerous. The presenilin protein
PS cDKO
RESEARCH MODELS Summary To generate postnatal forebrain-specific conditional double knock-out mice lacking both PSEN1 and PSEN2 (PS cDKO) mice, floxed PS1 (fPS1), αCaMKII-Cre transgenic mice and PS2-/- mice were bred together. This cross results in mice that have PSEN1 c
CNS-restricted PS1 cKO
RESEARCH MODELS Summary To create CNS-restricted PS1 conditional KO mice, a floxed fPS1 mouse (Yu et al., 2000; Yu et al., 2001) was crossed with Nestin-Cre transgenic mice, in which Cre is expressed in neural progenitor cells under the control of the Nestin promoter. In
PS1 conditional Knock-out
RESEARCH MODELS Summary PSEN1 conditional knockout (PS1 cKO) mice were generated from a Cre/lox recombination system. With this strategy PSEN1 expression is progressively eliminated from the neocortex and hippocampus beginning in the third postnatal week. Briefly, mice c
JAMIL UR REHMAN TAHIR
SHAIKH ZAYED HOSPITALLAHORE, Pakistan
PAPER Hefendehl JK, Neher JJ, Sühs RB, Kohsaka S, Skodras A, Jucker M
Homeostatic and injury-induced microglia behavior in the aging brain.
Aging Cell. 2014 Feb;13(1):60-9. Epub 2013 Sep 18 PubMed: 23953759PAPER Chung WS, Clarke LE, Wang GX, Stafford BK, Sher A, Chakraborty C, Joung J, Foo LC, Thompson A, Chen C, Smith SJ, Barres BA
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways.
Nature. 2013 Dec 19;504(7480):394-400. Epub 2013 Nov 24 PubMed: 24270812Alice Shapiro
Janssan R & DUnited States
PSEN1 R108Q
MUTATIONS PSEN1 73637740 GRCh37/hg19 rs200646139 G A Exon 4 Point, Missense Coding In cell assay, increased Aβ42 and Aβ40; in vitro, decreased Aβ42 production and undetectable Aβ40 production. Unknown. R108Q Alzheimer's Disease: Not ClassifiedAlzheimer's
PAPER Zimny A, Szewczyk P, Bladowska J, Trypka E, Wojtynska R, Leszek J, Sasiadek M
Quantitative evaluation of changes in the selected white matter tracts using diffusion tensor imaging in patients with Alzheimer's disease and mild cognitive impairment.
Neuroradiol J. 2012 Jul;25(3):300-10. PubMed: 24028982PAPER Chen R, Young K, Chao LL, Miller B, Yaffe K, Weiner MW, Herskovits EH
Prediction of conversion from mild cognitive impairment to Alzheimer disease based on bayesian data mining with ensemble learning.
Neuroradiol J. 2012 Mar;25(1):5-16. PubMed: 24028870PAPER Gattaz WF, Talib LL, Schaeffer EL, Diniz BS, Forlenza OV
Low platelet iPLA2 activity predicts conversion from mild cognitive impairment to Alzheimer's disease: a 4-year follow-up study.
J Neural Transm. 2013 Sep 15; PubMed: 24036895Current Filters
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