Preventing these peripheral phagocytes from creeping into the brain improves memory and ameliorates pathology in mouse models of Alzheimer’s.
Researchers have published RNA expression and processing data for the cerebellum and frontal cortex, and find that C9ORF72-based ALS and sporadic disease differ greatly.
Last year's ice bucket challenge for amyotrophic lateral sclerosis netted $220 million in donations for ALS charities, and the 2015 challenge is off to a strong start with $100,000 from Major League Baseball. Alzforum looks at how all that money is ...
Patients and charities hope people will want to cool off again this summer.
A year after social media campaign, what happened with the money?
A new mass spectrometry analysis provides the most thorough catalog yet of modifications to tau.
Findings suggest a severe blow to the head twists the protein's backbone, which may lead to neurofibrillary tangles.
Clever optical corrections reveal microglia and neurons through the intact mouse cranium.
A C-terminal fragment of APP recruits the protein APPL1 to endosomes, causing the enlarged, overactive vesicles seen early in Alzheimer’s disease.
The foundation recognizes the two researchers for their work on the molecular underpinnings Alzheimer’s disease.
Soluble APPα ramps up early in a mouse model of Fragile X Syndrome, and may promote symptoms of the disease. Blocking the peptide’s production could be a treatment strategy.
In some people, proteins in the cerebrospinal fluid trend toward an Alzheimer’s-like profile as early as age 45.
Mutant SOD1 prevents immature lysosomes from traveling along the axon and from maturing, leaving the cell with no means to clear broken-down mitochondria.
Adult mice walk the straight and narrow without reelin, but are more susceptible to Aβ.
The University of California, San Diego, is suing the University of Southern California and Alzheimer scientists.
No filters selected