Research Models

This database contains information about mouse models of Alzheimer’s disease, Amyotrophic Lateral Sclerosis, and related neurodegenerative diseases, as they are important tools for biomedical research and drug discovery. This database is a work in progress and will be expanded over time. To suggest a model, updates, or corrections, please contact us at


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Alzheimer's Mouse Models

Phenotype Summary

There is a large, ongoing effort to characterize disease models in order to better understand pathophysiology as well as to identify models suitable for investigating potential therapeutics. In support of this effort, we have collected information about core AD-related phenotypes and created interactive diagrams that facilitate comparisons. Please note, in the diagram below, as well as the others in this database, the position of the bar on the lifespan line reflects the earliest reported occurrence of the phenotype and not necessarily the age at onset.

Compare AD Models

Selected Phenotypes of Commonly Used Mouse Models

When visualized, these models will distributed over a 2-year timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.

ALS Research Models

Since the mid-'90s, dozens of mice have been generated that model various aspects of Amyotrophic Lateral Sclerosis, such as motor impairment and progressive degeneration of motor neurons. No model recapitulates the human disease perfectly, and some are more suitable than others for addressing a given experimental question. By organizing information related to the phenotypic characterization of ALS models, this resource conveys what is known about each one and facilitates comparison between models. In addition, the database serves as a forum for those using these mice to share their experiences and observations through the comment function.

Compare ALS Models



  1. Bettina Platt on PLB4 (hBACE1)
  2. Michael Sasner on Tau P301S (Line PS19)
  3. Thomas Bayer on Tg4-42
  4. Thomas Bayer on TBA42

Bulletin Board

  1. Regarding Choosing Alzheimer mouse model