Research Models


This database contains information about various animal models of Alzheimer’s disease and related neurodegenerative diseases, as they are important tools for biomedical research and drug discovery. This database is a work in progress and will be expanded over time. To suggest a model, updates, or corrections, please contact us at researchmodels@alzforum.org.

 

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Phenotype Summary

There is a large, ongoing effort to characterize the phenotypes of Alzheimer's disease models in order to better understand disease pathophysiology as well as to create models which can be used in preclinical therapeutic trials. To capture the results of these efforts, we have compiled information on some of the most relevant disease phenotypes and the approximate onset time of each in an interactive diagram that facilitates comparisons between models.

Visualize and Compare Models

Selected Phenotypes of Commonly Used Mouse Models

When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.