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Changes In Cortical Thickness Mirror Loss of Network Connectivity in AD
8 May 2008. The arrangement of linked brain regions into functional networks supports complex mental activity...
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SLICK Science—Imaging Advances May Aid Brain Research
8 May 2008. Peering through the dense thicket of axons and dendrites to figure out what individual neurons are up to in brain tissue is no mean feat...
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AD Immunotherapy: Toward Prevention, DNA-based Vaccines?
7 May 2008. Hopes of harnessing the immune system to fight Alzheimer disease took another hit...
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GO TO ALL RESEARCH NEWS  |
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In the spotlight
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Image of the Week: SLICK Neurons in Mouse Cortex
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A new method called Single-neuron Labeling with Inducible Cre-mediated Knockout, or SLICK for short, labels neurons with yellow fluorescent protein (YFP) while at the same time rendering them susceptible to conditional knockout of any gene. This slice of cortex from the SLICK-X mouse line shows that a subset of cortical neurons express YFP (which is actually green). The green neurons also express a Cre recombinase -estrogen receptor chimera. When crossed to any conditional knockout mice with a flox-flanked gene, knockout will happen only in green neurons and |
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not until the mice are fed the estrogen receptor ligand tamoxifen. The labeling of these genetically manipulated neurons with YFP makes it possible to study the morphology and the dynamics of structural plasticity in the brain. Any ideas for how this could be used to study neurodegeneration? Write a comment!
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Time to Envision Preventive Immunotherapy?
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A new study shows that a DNA-based, anti-Aβ vaccine protects AD transgenic mice that don't yet show AD pathology. The new vaccine represents a paradigm shift in the field, where all vaccines that have reached human testing thus far have been peptide-based and geared at treating mild to moderate AD. Looking beyond the published work, lead investigator Michael Agadjanyan proposes a novel preventive AD immunotherapy strategy with a vaccine that would deploy help from memory T cells developed in response to previous shots against common bugs such as tetanus, pertussis, the flu. Given |
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clinical setbacks of peptide-based treatment vaccines, is it time to consider prophylaxis and DNA vaccines as alternative research opportunities? Take on board Esther Landhuis's news story, a technical dialog about it, and Agadjanyan's comment on related AN1792 data, and ponder his future vaccination scheme. Then join the discussion—we cordially invite community feedback.
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Alzheimer Disease Research—How to Move Forward?
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Our Centennial series invited the field to train its eyes firmly on the future. We'd like to continue to solicit your sage advice—and wild ideas—for future directions in Alzheimer disease research. To this end, Alzforum scientific advisers past and present have helped us compile a summary table of ”What We Know/What We Don’t Know.” It’s a fresh and easy-to-use format to debate and discuss what the field has achieved and the most urgent priorities for future progress. |
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What's New
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Conference - Posted 8 May 2008
38th Annual Meeting of the Society for Neuroscience: Neuroscience 2008: 15-19 November 2008, Washington, DC, U.S.A. |
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Comments - Posted 8 May 2008
Read remarks by Arthur W. Toga about He Y et al.
PAPER: Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer's disease. |
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Comments - Posted 8 May 2008
Read remarks by Jurgen Gotz about Liang Z et al.
PAPER: Decrease of Protein Phosphatase 2A and its Association with Accumulation and Hyperphosphorylation of Tau in Down Syndrome. |
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Comments - Posted 8 May 2008
Read remarks by Alex Whitworth, Leo Pallanck about Yang Y et al.
PAPER: Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. |
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Comments - Posted 7 May 2008
Read remarks by Michael G. Agadjanyan about Pride M et al.
PAPER: Progress in the active immunotherapeutic approach to Alzheimer's disease: clinical investigations into AN1792-associated meningoencephalitis. |
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Comments - Posted 7 May 2008
Read remarks by David Holtzman about
Bayer AJ et al.
NEWS: AD Immunotherapy: Toward Prevention, DNA-based Vaccines? |
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Comments - Posted 7 May 2008
Read remarks by Rachelle Doody about Wilcock GK et al.
PAPER: Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial. |
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New Bookmarking Capability - Posted 5 May 2008
We have added the ability to share and tag Alzforum pages via Del.icio.us, Digg, Facebook, Google and Newsvine. Check out the topmost right-margin box under "Share & Bookmark."
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