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Bexarotene Revisited: Improves Mouse Memory But No Effect on Plaques
23 May 2013. Researchers reported in 2012 that the cancer drug bexarotene swiftly cleared amyloid-β and restored memory in transgenic mouse models of Alzheimer's disease...
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Paper Alert: B Vitamins Slow Atrophy in AD Vulnerable Brain Regions
23 May 2013. Results of a two-year clinical trial suggest that a mixture of B vitamins slows atrophy up to sevenfold in areas of the brain that are vulnerable to degeneration in AD...
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Controlling Blood Pressure May Lower Amyloid in ApoE4 Carriers
22 May 2013. Scientists report that reducing hypertension may ward off amyloid pathology in people who have the ε4 version of the ApoE gene...
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Scientists Create Human Stem Cells by Somatic Cell Nuclear Transfer
22 May 2013. Scientists report the first successful generation of human embryonic stem cells via somatic cell nuclear transfer...
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In the spotlight
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Bexarotene Redux: Mouse Memory Improves, Plaques Remain
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 Mouse hippocampus |
A 2012 Science paper set the Alzheimer’s field (and the popular press) abuzz by claiming that the cancer drug bexarotene rapidly eliminated amyloid-β plaques and rescued memory deficits in transgenic mouse models of AD. Now, four independent research groups report being unable to reproduce that plaque clearance. Three of the |
new reports confirm that bexarotene improves memory and lowers soluble Aβ in the brain. What does this mixed news mean for planned clinical trials of bexarotene? Read the full story. Image courtesy of Wikimedia Commons |
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Human Stem Cells Cloned by Somatic Cell Nuclear Transfer
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 Click to watch video of cloned heart cells |
Scientists have finally succeeded in making human embryonic stem cells via somatic cell nuclear transfer. These stem cells can develop into any tissue type, such as the muscle of a beating heart. What does this scientific achievement mean for cell therapies and disease models, and how do the new cells compare to the pluripotent stem cells derived without human cloning? Read the full story. Video credit: Cell, Tachibana et al. |
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Could AD Incidence Be Declining as Public Health Improves?
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In the face of a worldwide rising tide of dementia, here’s a drop of good news: The rate of new cases of Alzheimer's disease may be falling in the U.S. and Europe. Several studies suggest that incidence dipped 25-30 |
percent in the last two decades, although it remains to be seen whether these numbers will hold up. Researchers speculate that lifestyle and public health improvements have lowered risk. Others warn that rising obesity could reverse that trend. All agree that in the grand scheme of things, a small reduction in incidence will eventually be overwhelmed by the tsunami of an aging population. Read the full story. Image courtesy of Wikimedia Commons
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Neurodegeneration Workshop Explores New Treatment Strategies
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how to move scientific discoveries from the lab bench to the clinic. Multifactorial diseases such as AD likely "cannot be conquered by a single approach or drug," said Lennart Mucke of the Gladstone Institute of Neurological Disease, San Francisco, who co-organized the meeting with Pierluigi Nicotera of the German Center for Neurodegenerative Disease. Over the coming days, read Esther Landhuis' highlights, which cover new functions for BACE, novel therapeutic approaches centered around ubiquitination, acetylation, stress response pathways, and a longevity gene. Image courtesy of Lennart Mucke
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What's New
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Jobs - Posted 23 May 2013
PhD Student Position: AlzeCure/University of Gothenburg, Sweden. |
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Comments - Posted 22 May 2013
Read remarks by Lewis H. Kuller about
Rodrigue KM et al.
NEWS: Controlling Blood Pressure May Lower Amyloid in ApoE4 Carriers |
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Comments - Posted 22 May 2013
Read remarks by Kathleen Hayden about
Rodrigue KM et al.
NEWS: Controlling Blood Pressure May Lower Amyloid in ApoE4 Carriers |
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Comments - Posted 22 May 2013
Read remarks by Ashley Bush
NEWS: Larry Sparks, of Alzheimer’s-Cholesterol Fame, Dies at 63 |
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Comments - Posted 21 May 2013
Read remarks by Barry Greenberg
NEWS: Larry Sparks, of Alzheimer’s-Cholesterol Fame, Dies at 63 |
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Conferences - Posted 20 May 2013
23rd Neuropharmacology Conference 2013: 7-8 November 2013, Sheraton San Diego Hotel and Marina, San Diego, CA, U.S.A. |
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Conferences - Posted 20 May 2013
14th International Conference on Alzheimer's Drug Discovery: 9-10 September 2013, Jersey City, NJ, U.S.A. |
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Conferences - Posted 20 May 2013
Protein Aggregation Spectrum Disorders: 15-23 June 2013, University of Bonn, Bonn, Germany. |
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