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Research News
 
Garbage in, Garbage out: Cell Disposal System Linked to Longevity
3 July 2009. Research shows that from delicate yeast to mammalian gourmands, restricting caloric intake can dramatically increase longevity...
 
Rat Race—New Approach for Memory Enhancement?
3 July 2009. A report in today’s issue of Science describes an intriguing potential strategy for boosting memory...
 
Research Brief: Genetic Switch for Lysosomal Biogenesis and Activity?
2 July 2009. Dealing with trash poses a constant challenge not only for municipalities but also for neurons, where specialized organelles called lysosomes take on the task...
 
Research Brief: J&J to Buy Elan’s Aβ Immunotherapy Program
2 July 2009. Elan’s Alzheimer immunotherapy program (AIP) has gotten a booster...
 
GO TO ALL RESEARCH NEWS  
 
 
In the spotlight

SWAN Is Now Open!
The SWAN Alzheimer Knowledge Base of scientific hypotheses about AD can now be browsed freely without registration. Members will need to register only if they wish to publish comments in SWAN. This is a community-driven knowledge base of Alzheimer disease, in which researchers can annotate scientific hypotheses, claims, data, and information, putting these into the context of testable hypotheses and treatment discovery. SWAN relies upon a moderated community process to capture the collective insights of the AD field, and welcomes and explicitly models disagreements and differing interpretations of data.

Visit SWAN and have fun!

HBO Alzheimer's Project—The Alzforum Series
The Alzforum editors are delighted to present exclusive short films from "The Alzheimer's Project," sponsored by HBO Documentary Films and the National Institute on Aging of the National Institutes of Health, with support from the Alzheimer's Association, the Fidelity Charitable Gift Fund, and the Geoffrey Beene Gives Back Alzheimer's Initiative. This collection of short films features additional perspectives, review tutorials, and searching discussion of a broad range of current topics in Alzheimer disease science. Watch and listen as some of the pioneering scientists in the field speak directly to key issues in AD research and drug development today. We thank HBO's John Hoffman and Matthew Reineman for their dedicated leadership of this project.
It's a Tough Job
View larger image
When it comes to fending off groupies and paparazzi, scientists are old hands. Idolized by their peers since middle school for their stratospheric grades in science and math, scientists have never lacked for hot dates on a Friday night. By junior year in college, science majors are hounded by scouts from the nation's top high-tech labs dangling sacks of cash and Porsches. When it comes to crowd hysteria, the American Idol finale is nothing next to an M.I.T. thesis defense. Nobel laureates learn to steel
themselves against the unsettling experience of seeing their faces and personal scandals splashed across supermarket tabloids and, increasingly, in the blogosphere. Research institutes are groaning under the cost of maintaining bodyguards 24/7 for their star scientists. So we were a bit puzzled as to why Geoffrey Beene Gives Back felt scientists needed even more time in the limelight, with their Rock Stars of Science campaign, launched in the current issue of GQ magazine (a must-read at the Broad Institute). Until we realized it was all about a bunch of musicians—Joe Perry, Sheryl Crowe, will.i.am, Seal, Josh Groban—basking in the reflected glory of Science Idols, including Alzforum advisors and friends Jeffrey Cummings, Steve DeKosky, Sam Gandy, Ron Petersen, Dale Schenk, and Rudy Tanzi. We hope the campaign helps these musicians see an uptick in their iTunes downloads. The Rock Stars of Science website even lets you sign a statement of support and nominate a scientist to help other needy musicians. Rock on!

Above image shows Aerosmith's Joe Perry jamming with Rudy Tanzi and Francis Collins. Image credit: Geoffrey Beene Gives Back

Taking the Long View of Personal Genomics
Interested in having your DNA analyzed to learn your risk for a variety of health conditions including Alzheimer disease, diabetes, heart attack? With personal genetics testing services provided by co-sponsor Navigenics Inc., a company in Foster City, California, the Scripps Translational Science Institute, La Jolla, California, has launched a 20-year longitudinal study looking at how predictive information gleaned from personal genomics data influences behavior and lifestyle. Affymetrix and the Microsoft Corporation also co-sponsor the research. Through 30 September, members of the Alzforum community can sign up to participate in this study. For more information, please read our related news story posted earlier.
 
 
What's New

Comments - Posted 30 June 2009
Read remarks by Donna Wilcock about Puzzo D et al.
PAPER: Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.
 
Comments - Posted 30 June 2009
Read remarks by Michael Vitek, David A. Wink, Carol Colton about Puzzo D et al.
PAPER: Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.
 
Comments - Posted 30 June 2009
Read remarks by Thomas Beach about Beach TG et al.
PAPER: Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.
 
Comments - Posted 30 June 2009
Read remarks by Steve Barger about Matrone C et al.
NEWS: From Trophic to Toxic—Aβ Corrupts the NGF Receptor?
 
Comments - Posted 29 June 2009
Read remarks by Frederic Calon about He C et al.
PAPER: Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid.
 
Comments - Posted 29 June 2009
Read remarks by Gregory Cole about He C et al.
PAPER: Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid.
 
HBO Alzheimer's Project—The Alzforum Series - Posted 26 June 2009
Watch and listen to the HBO Alzheimer's Project—The Alzforum Series as some of the pioneering scientists in the field speak directly to key issues in AD research and drug development today.
 
Conferences - Posted 26 June 2009
10th International Conference of Alzheimer's and Parkinson's Diseases (AD/PD 2011): 9-13 March 2011, Barcelona, Spain.

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AlzRisk: An AD Epidemiology Database
The AlzRisk Epidemiology Database provides a publicly available collection of published studies on the impact of putative environmental risk factors and protective factors related to Alzheimer disease in longitudinal cohort studies.
AlzGene
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An up-to-date collection of all published genetic association studies.
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Topics in Neurodegeneration
Download Powerpoint Presentations created by top experts in neurodegenerative disease research. Available for educational or personal use. Edited by Daniel M. Michaelson, PhD, and Tobias Hartmann, PhD.

ISOA

The Drug Development Company Database and Tutorial represent the collaborative efforts of the Alzheimer's Drug Discovery Foundation (ADDF)/Institute for the Study on Aging (ISOA) and the Alzheimer Research Forum. Our thanks to ADDF, Jens Eckstein, and the Advisory Board for bringing this project to fruition.
ISOA
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If an AD drug were to show promise as a cognition booster in normal people, and side-effects are tolerable, would you take it?
 
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