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Immune Cell Receptor Gives Aβ a Toxic Edge
18 June 2013. Despite ample evidence implicating Aβ in Alzheimer’s pathology, scientists still struggle to understand how the peptide harms the brain.
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Lilly Halts Phase 2 Trial of BACE Inhibitor Due to Liver Toxicity
14 June 2013. Eli Lilly and Company announced yesterday that they have terminated the Phase 2 trial of their BACE inhibitor LY2886721 due to liver abnormalities.
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In Familial AD, Aβ Production Up, Clearance Down
14 June 2013. Researchers have long assumed that people with familial Alzheimer’s disease make too much Aβ42 in the brain, but they lacked proof.
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Prevalence of Dementia, AD, in China Eclipses Predictions
14 June 2013. A report on global disease burden found that the number of deaths in China due to Alzheimer’s disease and other dementias doubled between 1990 and 2010.
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GO TO ALL RESEARCH NEWS  |
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In the spotlight
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View Recording of Our Latest Webinar on Blood-Based Markers
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The full recording of this week's Webinar on blood-based markers for Alzheimer's disease is now live. Howard Fillit moderated and was joined for a panel discussion by Samantha Burnham, Sid O'Bryant, Simon Lovestone, |
Eugenia Trushina, and Henrik Zetterberg. Panelists' individual slide presentations are also available for viewing.
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Aβ Kinetics in Familial AD: Production Up, Clearance Down
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 Modeling Aβ kinetics |
Current thinking holds that early-onset AD is caused by overproduction of Aβ, while late-onset disease arises from failure to clear it. Researchers previously demonstrated the latter by measuring turnover of radiolabeled Aβ in the cerebrospinal fluid. Now, the same |
group applies the technique to familial disease and confirms that people with a presenilin mutation make more Aβ42 than do controls. Surprisingly, mutation carriers also clear the peptide from the brain more slowly, particularly when amyloid plaques are present. The data provide a sharper picture of the pathogenic mechanisms at work in familial AD, and strengthen ties between early- and late-onset disease. Read the full story. Image courtesy of Randall Bateman/Familial Adult Children Study
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Next Step Toward Combination Drug Trials
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To tackle a disease as complex as Alzheimer’s, many researchers believe it will be necessary not only to treat with multiple drugs, but also to develop experimental drugs together in combination. Researchers recently took steps down this road with related |
conferences in Washington, D.C., and New York City. They agreed to work toward combination trials on a shared platform that can test drugs from multiple companies. They discussed challenges, including finding surrogate biomarkers for fast readouts and lowering risk as a way to entice pharmaceutical companies to participate. Read the full story. |
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BACE Meeting Registration Closes Soon
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Cloister yourself in beautiful Bavaria for "BACE Proteases in Health and Disease." This meeting will be held 6-8 October 2013 at Kloster Seeon, a historic monastery-turned-conference venue. Registration ends 30 June 2013. |
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What's New
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Jobs - Posted 19 June 2013
Assistant or Associate Professor: Temple University School of Medicine, Philadelphia, Pennsylvania. |
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Comments - Posted 19 June 2013
Read remarks by Hugo Geerts about
Potter R et al.
NEWS: In Familial AD, Aβ Production Up, Clearance Down |
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Conferences - Posted 19 June 2013
BACE Proteases in Health and Disease: 6-8 October 2013, Kloster Seeon, Klosterweg, Bavaria, Germany. |
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Grants Update - Posted 18 June 2013
Program: 2013 MJFF Cognition Biomarkers RFA
Funds:
Deadline(s): Pre-proposals Due: June 19, 2013, 6:00 p.m. EST Full Application Invites Sent to Applicants: July 3, 2013 Full Applications Due (by invite only): August 14, 2013 Anticipated Award Announcement: October, 2013 Anticipated Funding: November, 2013 |
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Comments - Posted 18 June 2013
Read remarks by David Corbin about Lin AL et al.
PAPER: Methylene blue as a cerebral metabolic and hemodynamic enhancer. |
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Comments - Posted 18 June 2013
Read remarks by Jurgen Goetz about López-Otín C et al.
PAPER: The hallmarks of aging. |
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Comments - Posted 18 June 2013
Read remarks by Amirtha Ratnam about
Mueller U et al.
NEWS: Research Brief: Auguste D. Did Not Have Volga German Mutation |
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Comments - Posted 17 June 2013
Read remarks by Caroline M. Tanner about
Pichler I et al.
NEWS: Genotype-Based Meta-Analysis Suggests Serum Iron Protects Against PD |
SEE MORE |
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