 |
|
|
 |
Larry Sparks, of Alzheimer’s-Cholesterol Fame, Dies at 63
18 May 2013. Alzheimer's disease researchers expressed sadness this week at the sudden death of Larry Sparks...
|
| |
|
Skin Cancer Linked to Lower AD Risk—But Don't Hit the Beach Just Yet
17 May 2013. Skin cancer, a common and typically curable malignancy, may carry a fringe benefit—protection from Alzheimer’s disease...
|
| |
|
Study Finds Ways to Predict, Track Huntington’s Disease
17 May 2013. Anticipating future clinical trials for Huntington’s disease, researchers are seeking sensitive measures that will predict onset and track progression...
|
| |
|
Dementia Incidence Said to Drop as Public Health Improves
17 May 2013. Are fewer people getting Alzheimer’s disease now than they did 20 years ago?...
|
| |
GO TO ALL RESEARCH NEWS  |
|
|
 |
|
|
In the spotlight
|
 |
Webinar: Can Network Analysis Explain Alzheimer’s?
|
 |
 AD-specific molecular networks |
Though common genetic polymorphisms have been linked to Alzheimer's disease, scientists struggle to explain exactly how those variations influence biological function. Can network analysis help? In a complex disease such as AD, genetic and non-genetic factors conspire to disrupt biological pathways and processes. Identifying those disturbances could shed light on how risk genes cause disease. In the April 25 Cell, Valur Emilsson at the Icelandic Heart |
Association, with Eric Schadt at Mount Sinai, New York, report that they have identified molecular networks that associate with AD. Several contain known suspects, such as the microglial receptor TREM2 and the immunoglobulin-like CD33. They finger a new player, TYROBP, as a regulator of those network modules. The AD brain overproduces TYROBP and, intriguingly, it binds TREM2, and lies upstream of CD33. Lo and behold, on the same day in Neuron, researchers led by Rudy Tanzi and Ana Griciuc at Massachusetts General Hospital, Charlestown, report that microglia in the AD brain make more CD33 and that it hampers their ability to clear amyloid-β.
Join us for an Alzforum Webinar on Thursday, 23 May 2013 at 12:00 noon, U.S. Eastern time. Eric Schadt and Ana Griciuc will present their latest data and discuss them with Monica Carson, University of California, Riverside; John Hardy, University College London; and Jeremy Miller, Allen Institute for Brain Science, Seattle, Washington. Image courtesy of Cell Press.
We thank Cell Press for giving Alzforum readers temporary free access to these papers.
|
|
|
|
|
Could AD Incidence Be Declining as Public Health Improves?
|
|
 |
In the face of a worldwide rising tide of dementia, here’s a drop of good news: The rate of new cases of Alzheimer's disease may be falling in the U.S. and Europe. Several studies suggest that incidence dipped 25-30 |
percent in the last two decades, although it remains to be seen whether these numbers will hold up. Researchers speculate that lifestyle and public health improvements have lowered risk. Others warn that rising obesity could reverse that trend. All agree that in the grand scheme of things, a small reduction in incidence will eventually be overwhelmed by the tsunami of an aging population. Read the full story. Image courtesy of Wikimedia Commons
|
|
|
|
|
Neurodegeneration Workshop Explores New Treatment Strategies
|
|
how to move scientific discoveries from the lab bench to the clinic. Multifactorial diseases such as AD likely "cannot be conquered by a single approach or drug," said Lennart Mucke of the Gladstone Institute of Neurological Disease, San Francisco, who co-organized the meeting with Pierluigi Nicotera of the German Center for Neurodegenerative Disease. Over the coming days, read Esther Landhuis' highlights, which cover new functions for BACE, novel therapeutic approaches centered around ubiquitination, acetylation, stress response pathways, and a longevity gene. Image courtesy of Lennart Mucke
|
|
|
|
|
| |
|
| |
What's New
|
|
Conferences - Posted 20 May 2013
23rd Neuropharmacology Conference 2013: 7-8 November 2013, Sheraton San Diego Hotel and Marina, San Diego, CA, U.S.A. |
| |
|
Conferences - Posted 20 May 2013
14th International Conference on Alzheimer's Drug Discovery: 9-10 September 2013, Jersey City, NJ, U.S.A. |
| |
|
Conferences - Posted 20 May 2013
Protein Aggregation Spectrum Disorders: 15-23 June 2013, University of Bonn, Bonn, Germany. |
| |
|
Comments - Posted 17 May 2013
Read remarks by Javier DeFelipe about
Hunt RF et al.
NEWS: Stem Cells Treat Epileptic Symptoms in Mice |
| |
|
Comments - Posted 17 May 2013
Read remarks by Huaxi Xu about
White RS et al.
NEWS: Skin Cancer Linked to Lower AD Risk—But Don't Hit the Beach Just Yet |
| |
|
Conferences - Posted 15 May 2013
6th CNS Partnering and Deal Making Conference: 9-10 September 2013, Boston, MA, U.S.A. |
| |
|
Comments - Posted 14 May 2013
Read remarks by Diana Shineman
NEWS: Guidelines at Nature Aim to Stem Tide of Irreproducibility |
| |
|
Comments - Posted 14 May 2013
Read remarks by David Small
NEWS: Guidelines at Nature Aim to Stem Tide of Irreproducibility |
SEE MORE |
|
|
|
|
Home
Check out our upcoming Webinar: 
