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Antihypertensive therapy is associated with reduced rate of conversion to Alzheimer's disease in midregional proatrial natriuretic peptide stratified subjects with mild cognitive impairment.

Biol Psychiatry. 2011 Jul 15;70(2):145-51. PubMed: 21457948

PAPER Benedict C, Jacobsson JA, Rönnemaa E, Sällman-Almén M, Brooks S, Schultes B, Fredriksson R, Lannfelt L, Kilander L, Schiöth HB

The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men.

Neurobiol Aging. 2011 Jun;32(6):1159.e1-5. PubMed: 21458110

PAPER Beeri MS, Schmeidler J, Lesser GT, Maroukian M, West R, Leung S, Wysocki M, Perl DP, Purohit DP, Haroutunian V

Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology.

Neurobiol Aging. 2011 Mar 31; PubMed: 21458888

PAPER Kaden D, Munter LM, Reif B, Multhaup G

The amyloid precursor protein and its homologues: Structural and functional aspects of native and pathogenic oligomerization.

Eur J Cell Biol. 2011 Apr 1; PubMed: 21459473

PAPER Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J

Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse m

J Biol Chem. 2011 May 27;286(21):18414-25. PubMed: 21460223

PAPER Smart KA, Herrmann N, Lanctôt KL

Validity and responsiveness to change of clinically derived MDS scales in Alzheimer disease outcomes research.

J Geriatr Psychiatry Neurol. 2011 Jun;24(2):67-72. PubMed: 21460341

PAPER Ewers M, Cheng X, Zhong Z, Nural HF, Walsh C, Meindl T, Teipel SJ, Buerger K, He P, Shen Y, Hampel H

Increased CSF-BACE1 activity associated with decreased hippocampus volume in Alzheimer's disease.

J Alzheimers Dis. 2011;25(2):373-81. PubMed: 21460439

PAPER Tamboli IY, Tien NT, Walter J

Sphingolipid storage impairs autophagic clearance of Alzheimer-associated proteins.

Autophagy. 2011 Jun;7(6):645-6. PubMed: 21460623

PAPER Pagani L, Eckert A

Amyloid-Beta interaction with mitochondria.

Int J Alzheimers Dis. 2011;2011:925050. PubMed: 21461357

PAPER Bajić VP, Su B, Lee HG, Kudo W, Siedlak SL, Zivković L, Spremo-Potparević B, Djelic N, Milicevic Z, Singh AK, Fahmy LM, Wang X, Smith MA, Zhu X

Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease.

Cell Mol Biol Lett. 2011 Sep;16(3):359-72. PubMed: 21461981

Derek Streat

United States

Rudy Tanzi on Large Genetic Analysis Pays Off With New AD Risk Genes

COMMENT The two new Alzheimer's GWAS reports from the NIA-ADGC (Naj et al., 2011) and European consortium (Hollingworth et al., 2011) provide further support for roles of the innate immune system, cholesterol metabolism, and protein trafficking in the etiolo

Boris Schmidt on Dyeing Worms for an Extra-Long, Healthy Lifespan?

COMMENT The remarkable life-extending activity of the high curcumin concentrations requires additional experimental data for evaluation. Aqueous solutions of curcumin are not stable over three days (see decreased toxicity in zebrafish embryo); there are even repo

PAPER Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY, Lin JK

Stability of curcumin in buffer solutions and characterization of its degradation products.

J Pharm Biomed Anal. 1997 Aug;15(12):1867-76. PubMed: 9278892

PAPER Wu JY, Lin CY, Lin TW, Ken CF, Wen YD

Curcumin affects development of zebrafish embryo.

Biol Pharm Bull. 2007 Jul;30(7):1336-9. PubMed: 17603177