PAPER Choi H, Larsen B, Lin ZY, Breitkreutz A, Mellacheruvu D, Fermin D, Qin ZS, Tyers M, Gingras AC, Nesvizhskii AI
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Jens Pahnke on Paper Alert: In Vivo Human Data Shows Reduced Aβ Clearance in AD
COMMENT Congratulations! Very nice study showing the effects of reduced Aβ clearance in AD patients. Even in a small cohort and with a limited time for analysis, the effects are nicely stated. The precise mechanism underlying these findings have now to be describ
PAPER Islam MO, Kanemura Y, Tajria J, Mori H, Kobayashi S, Shofuda T, Miyake J, Hara M, Yamasaki M, Okano H
Characterization of ABC transporter ABCB1 expressed in human neural stem/progenitor cells.
FEBS Lett. 2005 Jul 4;579(17):3473-80. PubMed: 15950972Jean-François Foncin on San Diego: What—3 Percent? Money Woes Trump Science at SfN
COMMENT "...the NIH needs to make a greater commitment to AD, and if they split AD from the aging institute to do it, so be it." Of course they should. It makes no more sense to look at "aging" processes when doing research on Alzheimer's
APP (BAWT)
ANTIBODY monoclonal BAWT laboratory (<a href="http://www.biochemie.abi.med.uni-muenchen.de/research/junior/lichtenthaler/index.html" target="_new">Stefan Lichtenthaler</a>, Adolf Butenandt Institute, Ludwig Maximilians University, M
San Diego: Flexible N-Termini Key to Aβ42 Oligomer Toxicity?
CONFERENCE COVERAGE 2010-12-14 Conference Coverage Like squirmy toddlers dodging Grandma’s repeated attempts to photograph them, Aβ oligomers have proven evasive to the doting biophysicist. Indeed, progress has been slow for researchers toiling to discern the physical makeup of these n
San Diego: Tweakers and Tweezers—Grappling with Novel Aβ Therapies
CONFERENCE COVERAGE 2010-12-14 Conference Coverage Since the approval of cholinesterase inhibitors and memantine, no new therapy for Alzheimer’s disease has passed the clinical trial litmus test. But that does not stop ideas from coming. At the 40th annual meeting of the Society for Ne
PAPER Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.
Neuron. 2010 Nov 4;68(3):409-27. PubMed: 21040844PAPER Werry EL, Enjeti S, Halliday GM, Sachdev PS, Double KL
Effect of age on proliferation-regulating factors in human adult neurogenic regions.
J Neurochem. 2010 Nov;115(4):956-64. PubMed: 20831616PAPER Pioro EP, Brooks BR, Cummings J, Schiffer R, Thisted RA, Wynn D, Hepner A, Kaye R,
Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect.
Ann Neurol. 2010 Nov;68(5):693-702. PubMed: 20839238PAPER Hardingham GE, Bading H
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.
Nat Rev Neurosci. 2010 Oct;11(10):682-96. PubMed: 20842175PAPER Hamilton TJ, Wheatley BM, Sinclair DB, Bachmann M, Larkum ME, Colmers WF
Dopamine modulates synaptic plasticity in dendrites of rat and human dentate granule cells.
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18185-90. PubMed: 20921404PAPER Morris JA, Royall JJ, Bertagnolli D, Boe AF, Burnell JJ, Byrnes EJ, Copeland C, Desta T, Fischer SR, Goldy J, Glattfelder KJ, Kidney JM, Lemon T, Orta GJ, Parry SE, Pathak SD, Pearson OC, Reding M, Shapouri S, Smith KA, Soden C, Solan BM, Weller J, Takahashi JS, Overly CC, Lein ES, Hawrylycz MJ, Hohmann JG, Jones AR
Divergent and nonuniform gene expression patterns in mouse brain.
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19049-54. PubMed: 20956311PAPER Savrasova AV, Lushnikova IV, Isaeva EV, Skibo GG, Isaev DS, Kostyuk PG
The effect of neuraminidase blocker on gabazine-induced seizures in rat hippocampus.
Fiziol Zh. 2010;56(4):14-8. PubMed: 20964139PAPER Haigis MC, Yankner BA
The aging stress response.
Mol Cell. 2010 Oct 22;40(2):333-44. PubMed: 20965426Current Filters
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