PAPER Ferrer I, Kulisevsky J, Gonzalez G, Escartin A, Chivite A, Casas R
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PAPER Hurshman Babbes AR, Powers ET, Kelly JW
Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.
Biochemistry. 2008 Jul 1;47(26):6969-84. Epub 2008 Jun 7 PubMed: 18537267PAPER Quintas A, Saraiva MJ, Brito RM
The tetrameric protein transthyretin dissociates to a non-native monomer in solution. A novel model for amyloidogenesis.
J Biol Chem. 1999 Nov 12;274(46):32943-9. PubMed: 10551861Tim Bartels, Dennis Selkoe on Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.
COMMENT There are some interesting points in the study from the Sun lab that seem to add to general themes found in diseases associated with amyloid aggregation. In all of these diseases, inclusions consisting of an endogenously produced protein mark the progress
PAPER Lu J, Yu Y, Zhu I, Cheng Y, Sun PD
Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5189-94. Epub 2014 Mar 24 PubMed: 24706838Tao Ma on PPARγ recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement.
COMMENT These findings are very interesting and have added to the growing body of evidence linking metabolic disease syndromes to cognitive dysfunction. The authors highlight and propose that the association between a phosphorylated form of ERK kinase and PPARγ p
Katie Evans
Katiebrisbane, Australia
Claire Lucas
Alzheimer's Research UKUnited Kingdom
PAPER Kasanuki K, Iseki E, Kondo D, Fujishiro H, Minegishi M, Sato K, Katsuse O, Hino H, Kosaka K, Arai H
Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies.
Neurosci Lett. 2014 May 21;569:68-73. Epub 2014 Apr 2 PubMed: 24704327PAPER Malek N, Swallow D, Grosset KA, Anichtchik O, Spillantini M, Grosset DG
Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease- a systematic review.
Acta Neurol Scand. 2014 Aug;130(2):59-72. Epub 2014 Apr 5 PubMed: 24702516PAPER van Dis V, Kuijpers M, Haasdijk ED, Teuling E, Oakes SA, Hoogenraad CC, Jaarsma D
Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons.
Acta Neuropathol Commun. 2014 Apr 7;2:38. PubMed: 24708899PAPER Ludvigsson JF, Mariosa D, Lebwohl B, Fang F
No association between biopsy-verified celiac disease and subsequent amyotrophic lateral sclerosis--a population-based cohort study.
Eur J Neurol. 2014 Jul;21(7):976-82. Epub 2014 Apr 7 PubMed: 24708265PAPER Kobayakawa Y, Sakumi K, Kajitani K, Kadoya T, Horie H, Kira JI, Nakabeppu Y
Galectin-1 deficiency improves axonal swelling of motor neurons in SOD1(G93A) transgenic mice.
Neuropathol Appl Neurobiol. 2014 Feb 12; PubMed: 24707896PAPER Miller RG, Brooks BR, Swain-Eng RJ, Basner RC, Carter GT, Casey P, Cohen AB, Dubinsky R, Forshew D, Jackson CE, Kasarskis E, Procaccini NJ, Sanjak M, Tolin FP
Quality improvement in neurology: amyotrophic lateral sclerosis quality measures. Report of the Quality Measurement and Reporting Subcommittee of the American Academy of Neurology.
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):165-8. Epub 2014 Apr 7 PubMed: 24707820PAPER Akimoto C, Volk AE, van Blitterswijk M, Van den Broeck M, Leblond CS, Lumbroso S, Camu W, Neitzel B, Onodera O, van Rheenen W, Pinto S, Weber M, Smith B, Proven M, Talbot K, Keagle P, Chesi A, Ratti A, van der Zee J, Alstermark H, Birve A, Calini D, Nordin A, Tradowsky DC, Just W, Daoud H, Angerbauer S, DeJesus-Hernandez M, Konno T, Lloyd-Jani A, de Carvalho M, Mouzat K, Landers JE, Veldink JH, Silani V, Gitler AD, Shaw CE, Rouleau GA, van den Berg LH, Van Broeckhoven C, Rademakers R, Andersen PM, Kubisch C
A blinded international study on the reliability of genetic testing for GGGGCC-repeat expansions in C9orf72 reveals marked differences in results among 14 laboratories.
J Med Genet. 2014 Jun;51(6):419-24. Epub 2014 Apr 4 PubMed: 24706941Current Filters
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