PAPER Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, Mormino EC, O'Neil JP, Janabi M, Karydas A, Growdon ME, Jang JY, Huang EJ, Dearmond SJ, Trojanowski JQ, Grinberg LT, Gorno-Tempini ML, Seeley WW, Miller BL, Jagust WJ

Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD.

Neurology. 2011 Dec 6;77(23):2034-42. PubMed: 22131541

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A tale of two tracers: the age of wisdom for dementia diagnosis?

Neurology. 2011 Dec 6;77(23):2008-9. PubMed: 22131545

Michal Schwartz on Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.

COMMENT Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). The work by J.P. Julien and colleagues very elegantly shows a linkage between the abnormal regulation of TDP-43 a

PAPER Oh JH, Lee TJ, Park JW, Kwon TK

Withaferin A inhibits iNOS expression and nitric oxide production by Akt inactivation and down-regulating LPS-induced activity of NF-kappaB in RAW 264.7 cells.

Eur J Pharmacol. 2008 Dec 3;599(1-3):11-7. PubMed: 18838070

PAPER Uranishi H, Tetsuka T, Yamashita M, Asamitsu K, Shimizu M, Itoh M, Okamoto T

Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator.

J Biol Chem. 2001 Apr 20;276(16):13395-401. PubMed: 11278855

PAPER Yassa MA, Stark SM, Bakker A, Albert MS, Gallagher M, Stark CE

High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment.

Neuroimage. 2010 Jul 1;51(3):1242-52. PubMed: 20338246

PAPER Putcha D, Brickhouse M, O'keefe K, Sullivan C, Rentz D, Marshall G, Dickerson B, Sperling R

Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults.

J Neurosci. 2011 Nov 30;31(48):17680-8. PubMed: 22131428

Joe Quinn

Oregon Health Sciences University
United States

PAPER Martel MA, Wyllie DJ, Hardingham GE

In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death.

Neuroscience. 2009 Jan 12;158(1):334-43. PubMed: 18378405

PAPER Bektemirova MS, Osidze DF, Pille ER, Nadaichik LV, Matevosyan KS, Nagieva FG, Bogomolova NN, Boriskin YS, Yanova NN

Properties of rabies virus (MNIIVP-74 strain) adapted to Japanese quail embryo cell culture.

Arch Virol. 1979;61(1-2):61-8. PubMed: 518300

Research Brief: Hippocampal Hyperactivity Tied to Early MCI Atrophy

RESEARCH NEWS 2011-12-02 Research News Dying neurons typically display little activity, but Alzheimer’s disease researchers have puzzled over a strange surge of hippocampal firing in some seniors at the cusp of mental decline. A functional brain imaging study in the November 30 J

DC: Is Alzheimer's Rooted in the Early Life?

CONFERENCE COVERAGE 2011-12-02 Conference Coverage Could Alzheimer’s disease begin in the womb? One theory for the origin of some neurological diseases, such as schizophrenia (see Brown and Derkits, 2010) and autism (see Atladóttir et al., 2010), is that an infection in the mother alte

DC: Targeting Toxic Extrasynaptic Signaling in HD and AD

CONFERENCE COVERAGE 2011-12-02 Conference Coverage In neuronal transmission, as in real estate, location is everything. When N-methyl D-aspartate (NMDA) glutamate receptors sit in the synapse, they behave like good citizens, activating signaling pathways that promote memory formation a

TDP-43 Hangs Out With NF-κB, Puts Innate Immunity Into Hyperdrive

RESEARCH NEWS 2011-12-02 Research News TAR DNA binding protein 43, the RNA-binding protein linked to amyotrophic lateral sclerosis, is in the middle of an abnormal innate immune response that compromises the spinal cord of people with the disease, according to a paper published N

PAPER Zhang Q, Huang WD, Lv XY, Yang YM

Puerarin Protects Differentiated PC12 Cells from Hydrogen Peroxide-induced Apoptosis through the PI3K/Akt Signaling Pathway.

Cell Biol Int. 2011 Nov 30; PubMed: 22126839