F18 PET Tracers, New MRI Method to Expand Reach of Brain Imaging

RESEARCH NEWS 2011-11-22 Research News Beacons for possible future dementia often go unnoticed because seeing them requires imaging technology only available in specialized research centers. The tide may soon turn, though. New developments in amyloid imaging with F18-labeled posi

EEG: Coming in From the Margins of Alzheimer’s Research?

CONFERENCE COVERAGE 2011-11-22 Conference Coverage Regular visitors to Alzforum will be familiar with the use of positron emission tomography, magnetic resonance imaging, and cerebrospinal fluid measurements as markers for Alzheimer’s disease (AD). But these three are not the only AD b

Paul Newhouse

Vanderbilt University
Nashville, United States

PAPER Martin LJ, Chen K, Liu Z

Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation.

J Neurosci. 2005 Jul 6;25(27):6449-59. PubMed: 16000635

PAPER Martin LJ, Liu Z

Injury-induced spinal motor neuron apoptosis is preceded by DNA single-strand breaks and is p53- and Bax-dependent.

J Neurobiol. 2002 Feb 15;50(3):181-97. PubMed: 11810634

PAPER Levenson JM, Roth TL, Lubin FD, Miller CA, Huang IC, Desai P, Malone LM, Sweatt JD

Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus.

J Biol Chem. 2006 Jun 9;281(23):15763-73. PubMed: 16606618

PAPER Kondo T, Bobek MP, Kuick R, Lamb B, Zhu X, Narayan A, Bourc'his D, Viegas-Péquignot E, Ehrlich M, Hanash SM

Whole-genome methylation scan in ICF syndrome: hypomethylation of non-satellite DNA repeats D4Z4 and NBL2.

Hum Mol Genet. 2000 Mar 1;9(4):597-604. PubMed: 10699183

Lisa Chobanin

Health4Brands Chelsea
New York, United States

jan-erik nyström

AstraZeneca
Södertälje, Sweden

PAPER Atakhanov Sh, Adzhimollaev TA, Zimina RV, Nikolaeva LF

[Determination of the degree of sonoluminescence of blood plasma in myocardial infarct].

Ter Arkh. 1978;50(8):20-4. PubMed: 694756

liang zou

China

Does Epigenetic Methylation Shut Down Dying Motor Neurons?

RESEARCH NEWS 2011-11-21 Research News Like the caretaker of a condemned building shutting off the lights for the last time, DNA methyltransferases shut off motor neuron genes during apoptosis. This is according to a paper in the November 16 Journal of Neuroscience by Lee Martin

Research Brief: Dexpramipexole Results Look Promising for ALS

RESEARCH NEWS 2011-11-20 Research News Dexpramipexole, a candidate drug for amyotrophic lateral sclerosis, seems to have aced its Phase 2 test. In today’s Nature Medicine online, Knopp Biosciences of Pittsburgh, Pennsylvania, and the Northeast Amyotrophic Lateral Sclerosis (NEALS

PAPER Lee DW, Notter SA, Thiruchelvam M, Dever DP, Fitzpatrick R, Kostyniak PJ, Cory-Slechta DA, Opanashuk LA

Subchronic polychlorinated biphenyl (aroclor 1254) exposure produces oxidative damage and neuronal death of ventral midbrain dopaminergic systems.

Toxicol Sci. 2012 Feb;125(2):496-508. PubMed: 22094459

PAPER Khalil M, Teunissen C, Langkammer C

Iron and neurodegeneration in multiple sclerosis.

Mult Scler Int. 2011;2011:606807. PubMed: 22096640