PAPER Matarazzo M, Pérez-Soriano A, Vafai N, Shahinfard E, Cheng KJ, McKenzie J, Neilson N, Miao Q, Schaffer P, Shinotoh H, Kordower JH, Sossi V, Stoessl AJ
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PAPER Tropea TF, Hartstone W, Amari N, Baum D, Rick J, Suh E, Zhang H, Paul RA, Han N, Zack R, Brody EM, Albuja I, James J, Spindler M, Deik A, Aamodt WW, Dahodwala N, Hamedani A, Lasker A, Hurtig H, Stern M, Weintraub D, Vaswani P, Willis AW, Siderowf A, Xie SX, Van Deerlin V, Chen-Plotkin AS
Genetic and phenotypic characterization of Parkinson's disease at the clinic-wide level.
NPJ Parkinsons Dis. 2024 May 3;10(1):97. PubMed: 38702337Jennifer Rauch on Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
COMMENT This is an interesting mechanistic study by Cooper et al., looking at the interactions between tau and SORL1, a protein with known associations to AD. This new study expands on the authors’ prior biochemical work looking at the tau-LRP1 interaction and it
Sam Gandy on Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
COMMENT SORL1 is best known as a modulator of APP sorting, metabolism, and amyloidogenesis. This new data extends the action of SORL1 to tauopathy, providing an unexpected convergence of two key pathways in Alzheimer pathogenesis. Tau aggregates form in neurons a
Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
RESEARCH NEWS 2024-05-04 Research News Over the last few decades, evidence has emerged to peg the sortilin-related receptor, SORL1, as a risk factor for Alzheimer’s disease and even as the fourth gene for familial AD. SORL1 helps traffic amyloid precursor protein through the endo
Marc Diamond on Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
COMMENT The take-home message for me is that any assertion of a single protein “receptor” for tau at the surface should be taken with a grain of salt. This paper purports to show that SORL1 is a “receptor” for tau. However, one of the final figures indicates that
Gregory Petsko on Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
COMMENT The paper is interesting and potentially important. That retromer-regulated trafficking is important in tauopathies, including Alzheimer’s disease, is well-established (e.g., Mishra et al., 2023). However, the direct binding of tau to SORL1 is a new findi
Kenneth Kosik on Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
COMMENT This paper by J.M. Cooper et al. is a well-executed study that advances our thinking about the route tau travels once internalized. In essence, the problem we face is that, internalized via LRP1 through which it enters endosomes, tau must escape the endos
George King
Atlanta, United States
PAPER Jacobsen L, Madsen P, Jacobsen C, Nielsen MS, Gliemann J, Petersen CM
Activation and functional characterization of the mosaic receptor SorLA/LR11.
J Biol Chem. 2001 Jun 22;276(25):22788-96. Epub 2001 Apr 9 PubMed: 11294867PAPER Alzghool OM, Aarnio R, Helin JS, Wahlroos S, Keller T, Matilainen M, Solis J, Danon JJ, Kassiou M, Snellman A, Solin O, Rinne JO, Haaparanta-Solin M
Correction: Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA.
EJNMMI Res. 2024 May 3;14(1):44. PubMed: 38700617PAPER Lee CY, Chan L, Hu CJ, Hong CT, Chen JH
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials.
Aging (Albany NY). 2024 May 2;16 PubMed: 38700503PAPER Meng X, Cui W, Liang Q, Zhang B, Wei Y
Trends and hotspots in tea and Alzheimer's disease research from 2014 to 2023: A bibliometric and visual analysis.
Heliyon. 2024 May 15;10(9):e30063. Epub 2024 Apr 23 PubMed: 38699003PAPER Xu J, Chen Y, Shi Y, Sun A, Yang Y, Boustani M, Su J, Zhang P
Associations Between Neuroinflammation-Related Conditions and Alzheimer's Disease: A Study of US Insurance Claims Data.
J Alzheimers Dis. 2024 Apr 30; PubMed: 38701142PAPER Espay AJ, Herrup K, Imbimbo BP, Kepp KP, Daly T
Recalibrating the Risk-Benefit Profiles of Lecanemab and Donanemab: Scales, Immunoreactivity, and Changes in Amyloid-β42.
J Alzheimers Dis. 2024 May 2; PubMed: 38701151Current Filters
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