340258 RESULTS
RESEARCH NEWS 2024-10-31 Research News TMEM106b’s rap sheet is growing. Some of its genetic variants are linked to both Alzheimer’s disease and frontotemporal dementia, and fibrils of this lysosomal protein accumulate in several neurodegenerative diseases. Now, in an October 18 p
PAPER Du M, Akerman SC, Fare C, Ruan L, Vidensky S, Mamedova L, Lee J, Rothstein JD
PAPER Snellman A, Tuisku J, Koivumäki M, Wahlroos S, Aarnio R, Rajander J, Karrasch M, Ekblad LL, Rinne JO
PAPER Lopera F, Arboleda-Velasquez JF
PAPER Cochran JN, Greicius MD, Goate AM
COMMENT The current work is built on the creation of a knock-in mouse model expressing a HaloTag-tagged APOE, thus allowing its in situ visualization and biochemical purification. Using this elegant system, coupled with various imaging modality and biochemical me
COMMENT Genetics studies point to endo-lysosomal, immune, and lipid pathways as dysfunctional in AD, and many of these genes are highly expressed in glia. In this study, Kaji et al., perform an impressive amount of experiments to show microglial cells are necessa
COMMENT This is a fantastic study from the Simons lab that brings together a lot of key observations into an attractive theoretical framework for how APOE and microglia conspire to form nascent amyloid fibrils to seed pathology. It begs the question of whether de
COMMENT Kaji and colleagues use a variety of experimental approaches to demonstrate that, in the AD brain, lipid-associated ApoE is phagocytically internalized into microglia together with lower-order polymers of Aβ, and that ApoE facilitates the dense fibrillar
PAPER Park JH
PAPER Serebrovska Z, Xi L, Fedoriuk M, Dosenko V, Shysh A, Khetsuriani M, Porkhalo D, Savchenko A, Goncharov S, Utko N, Virko S, Kholin V, Egorov E, Koval R, Maksymchuk O
PAPER Gilboa T, Ter-Ovanesyan D, Wang SC, Whiteman S, Kannarkat GT, Church GM, Chen-Plotkin AS, Walt DR
PAPER Jambi EJ, Afzal M, Al-Abbasi FA, Moglad E, Al-Qahtani SD, Almalki NA, Alzarea SI, Imam F, Sayyed N, Kazmi I
PAPER Zhu B, Park JM, Coffey SR, Russo A, Hsu IU, Wang J, Su C, Chang R, Lam TT, Gopal PP, Ginsberg SD, Zhao H, Hafler DA, Chandra SS, Zhang L
PAPER Isidro F
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