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Do Microbes in the Gut Trigger Parkinson’s Disease?

RESEARCH NEWS 2016-12-02 Add Private note Add An editorial note Research News Microbial minions teeming in the gut seem to factor in an ever-growing list of health problems, from obesity to heart disease to depression. According to a study published December 1 in Cell, microbes ...

New Tracer Shows Disrupted Glutamate Dynamics Near Plaques

RESEARCH NEWS 2016-12-02 Add Private note Add An editorial note Research News Amyloid plaques are thought to precipitate cognitive decline by creating a toxic microenvironment for neurons, but scientists are still working out the exact mechanism. Now, using a new, high-resolution ...

NSE-APP751

RESEARCH MODELS Summary This model was the first reported APP transgenic mouse. It overexpressed the human APP 751 isoform, which includes the Kunitz serine protease inhibitor domain. The transgene was expressed throughout the brain from a rat neural-specific enolase ...

ITI-007

THERAPEUTICS Add Private note Add An editorial note Bristol-Myers Squibb Intra-Cellular Therapies, Inc. Small Molecule Other Neurotransmitters In 2014, Intra-Cellular Therapies ran a Phase 1/2 dose-escalation study of up to 30 mg/d in 30 old healthy volunteers and ...

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