PAPER Benilova I, De Strooper B
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PAPER Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, Hyman BT, Shatz CJ
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.
Science. 2013 Sep 20;341(6152):1399-404. PubMed: 24052308PAPER Fernández-Martínez M, Elcoroaristizabal Martín X, Blanco Martín E, Galdos Alcelay L, Ugarriza Serrano I, Gómez Busto F, Alvarez-Álvarez M, Molano Salazar A, Bereincua Gandarias R, Inglés Borda S, Uterga Valiente JM, Indakoetxea Juanbeltz B, Gómez Beldarraín MÁ, Moraza López J, Barandiarán Amillano M, M de Pancorbo M
Oestrogen receptor polymorphisms are an associated risk factor for mild cognitive impairment and Alzheimer disease in women APOE {varepsilon}4 carriers: a case-control study.
BMJ Open. 2013;3(9):e003200. PubMed: 24052609PAPER Mapelli D, Di Rosa E, Nocita R, Sava D
Cognitive stimulation in patients with dementia: randomized controlled trial.
Dement Geriatr Cogn Dis Extra. 2013;3(1):263-71. PubMed: 24052800PAPER Kannan M, Manivel P, Geetha K, Muthukumaran J, Rao HS, Krishna R
Synthesis and in silico evaluation of 1N-methyl-1S-methyl-2-nitroethylene (NMSM) derivatives against Alzheimer disease: to understand their interacting mechanism with acetylcholinesterase.
J Chem Biol. 2012;5(4):151-66. PubMed: 24052808Charles Weber
United States
Douglas Galasko on NIH Funds Prevention Trials and Translational Studies
COMMENT Several of these awards focus on systems biology approaches, using human or animal model tissue, to identify networks and pathways implicated in Alzheimer's disease. Drs Bennett and De Jager have published several papers illustrating the opportunites
Victor L. Villemagne on Tau Tracer May Light Up All Tauopathies
COMMENT The latest entry in the roster of tau imaging agents is a 11 C tracer: 11 C-PBB3, based on a phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs) scaffold. These compounds are characterized by a π-electron-conjugated backbone with a specific
Moustapha Cisse on Immune Receptor Binds Aβ Oligomers, Spurs Synaptic Loss
COMMENT Aβ oligomers bind to multiple proteins and have diverse effects in cell culture and animal models of the disease, depending on a plethora of variables such as oligomer species, length of exposure of neurons to oligomers, mutations harbored by transgenic m
PAPER Rust MB, Gurniak CB, Renner M, Vara H, Morando L, Görlich A, Sassoè-Pognetto M, Banchaabouchi MA, Giustetto M, Triller A, Choquet D, Witke W
Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics.
EMBO J. 2010 Jun 2;29(11):1889-902. PubMed: 20407421Cellular Pruning Shears Reshape Connections in Adults
RESEARCH NEWS 2013-09-20 Research News The cortex is a remarkably adaptable structure. Deprive a small region of input, and axons from neighboring areas undergo exuberant outgrowth and pruning, in order to reactivate the freed-up real estate. While scientists know what causes new
NIH Funds Prevention Trials and Translational Studies
COMMUNITY NEWS 2013-09-20 Community News The National Institutes of Health announced September 18 that it will allocate $45 million in new funding to advance Alzheimer’s research. The bulk of the money will help support therapeutic prevention trials in cognitively healthy populati
Immune Receptor Binds Aβ Oligomers, Spurs Synaptic Loss
RESEARCH NEWS 2013-09-20 Research News The list of claimed Aβ receptors is growing, and the latest addition hails from the immune system. In the September 20 Science, Carla Shatz of Stanford University, Palo Alto, California, and collaborators elsewhere report Aβ oligomer binding
Tau Tracer May Light Up All Tauopathies
RESEARCH NEWS 2013-09-20 Research News Researchers attempting to spy tau pathology in the living human brain have come up with a trio of options. In the September 18 Neuron, brain imagers from the National Institute of Radiological Sciences in Chiba, Japan, present the first publ
Antony Cooper
Australia
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