PAPER Michaelis EK

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging.

Prog Neurobiol. 1998 Mar;54(4):369-415. PubMed: 9522394

PAPER Cummings JL, Kaufer D

Neuropsychiatric aspects of Alzheimer's disease: the cholinergic hypothesis revisited.

Neurology. 1996 Oct;47(4):876-83. PubMed: 8857712

Carla d'Avanzo

MGH harvard medical school
United States

Tiffany Wyndham

Forney, United States

Char Glenn

Nob Hill Internal Medicine
Beaverton, United States

Takashi Horiguchi

�National Institue of Radiological Sciences
Japan

James McKay

Australia

MAPT R370W

MUTATIONS MAPT 44061278 GRCh37/hg19 rs17651549 C T g.97318C> T g.94492C> T Exon 4a Point, Missense Coding Unknown. Not applicable. R370W Frontotemporal Dementia: BenignNone This variant in exon 4a of MAPT is thought to be benign. Originally described accordin

MAPT P301P

MUTATIONS MAPT 44087756 GRCh37/hg19 rs63751395 G A g.123791G> A g.120970G> A Exon 10 Point, Silent Coding No change in the ratio of 3-repeat (3R) to 4-repeat (4R) tau isoforms. Patient had severe neuronal loss in the frontal and temporal cortices, globus pall

Paper Alert: New Alzheimer’s Genes Published

RESEARCH NEWS 2013-10-27 Research News A meta-analysis of four large Alzheimer’s genome-wide association studies has doubled the number of genetic loci strongly linked to the disease. The findings were previously reported at the Alzheimer’s Association International Conference, h

PAPER Clerc MT, Deprez M, Leuba G, Lhermitte B, Lopez U, von Gunten A

Atypical association of semantic dementia, corticobasal syndrome, and 4R tauopathy.

Neurocase. 2013 Oct 24; PubMed: 24156410

PAPER Cheruiyot A, Lee JA, Gao FB, Ahmad ST

Expression of mutant CHMP2B, an ESCRT-III component involved in frontotemporal dementia, causes eye deformities due to Notch misregulation in Drosophila.

FASEB J. 2013 Oct 24; PubMed: 24158394

PAPER Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in Neurons.

Science. 2013 Nov 22;342(6161):979-83. PubMed: 24158909

PAPER Lee J, Kim SY, Hwang KJ, Ju YR, Woo HJ

Prion Diseases as Transmissible Zoonotic Diseases.

Osong Public Health Res Perspect. 2013 Feb;4(1):57-66. PubMed: 24159531

PAPER Pino E, Amamoto R, Zheng L, Cacquevel M, Sarria JC, Knott GW, Schneider BL

FOXO3 determines the accumulation α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.

Hum Mol Genet. 2013 Oct 24; PubMed: 24158851