PAPER Kimura N, Okabayashi S, Ono F

Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function.

Am J Pathol. 2012 Feb;180(2):550-61. PubMed: 22182700

PAPER Pan Z, Chang C

Gender and the regulation of longevity: Implications for autoimmunity.

Autoimmun Rev. 2011 Dec 11; PubMed: 22182796

PAPER Chui HC, Zheng L, Reed BR, Vinters HV, Mack WJ

Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review.

Alzheimers Res Ther. 2012 Jan 4;3(6):36. PubMed: 22182734

PAPER van Geldorp B, Konings EP, van Tilborg IA, Kessels RP

Associative working memory and subsequent episodic memory in Alzheimer's disease.

Neuroreport. 2012 Jan 25;23(2):119-23. PubMed: 22182961

PAPER Stein J, Luppa M, Luck T, Maier W, Wagner M, Daerr M, van den Bussche H, Zimmermann T, Köhler M, Bickel H, Mösch E, Weyerer S, Kaufeler T, Pentzek M, Wiese B, Wollny A, König HH, Riedel-Heller SG

The assessment of changes in cognitive functioning: age-, education-, and gender-specific reliable change indices for older adults tested on the CERAD-NP battery: results of the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (Age

Am J Geriatr Psychiatry. 2012 Jan;20(1):84-97. PubMed: 22183013

PAPER Snigdha S, Astarita G, Piomelli D, Cotman CW

Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain.

Neuroscience. 2012 Jan 27;202:326-33. PubMed: 22183056

PAPER de Groot NS, Castillo V, Graña-Montes R, Ventura S

AGGRESCAN: method, application, and perspectives for drug design.

Methods Mol Biol. 2012;819:199-220. PubMed: 22183539

PAPER Amoo G, Akinyemi RO, Onofa LU, Akinyemi JO, Baiyewu O, Ogunlesi AO, Ogunniyi A

Profile of clinically-diagnosed dementias in a neuropsychiatric practice in Abeokuta, South-Western Nigeria.

Afr J Psychiatry (Johannesbg). 2011 Nov;14(5):377-82. PubMed: 22183468

PAPER Sato K, Tanabe C, Yonemura Y, Watahiki H, Zhao Y, Yagishita S, Ebina M, Suo S, Futai E, Murata M, Ishiura S

Localization of mature neprilysin in lipid rafts.

J Neurosci Res. 2012 Apr;90(4):870-7. PubMed: 22183801

PAPER Ma SL, Pastorino L, Zhou XZ, Lu KP

Prolyl Isomerase Pin1 Promotes Amyloid Precursor Protein (APP) Turnover by Inhibiting Glycogen Synthase Kinase-3β (GSK3β) Activity: NOVEL MECHANISM FOR Pin1 TO PROTECT AGAINST ALZHEIMER DISEASE.

J Biol Chem. 2012 Mar 2;287(10):6969-73. PubMed: 22184106

PAPER Schroeter ML, Vogt B, Frisch S, Becker G, Barthel H, Mueller K, Villringer A, Sabri O

Executive deficits are related to the inferior frontal junction in early dementia.

Brain. 2012 Jan;135(Pt 1):201-15. PubMed: 22184615

PAPER Guillot-Sestier MV, Sunyach C, Ferreira ST, Marzolo MP, Bauer C, Thevenet A, Checler F

α-Secretase-derived Fragment of Cellular Prion, N1, Protects against Monomeric and Oligomeric Amyloid β (Aβ)-associated Cell Death.

J Biol Chem. 2012 Feb 10;287(7):5021-32. PubMed: 22184125

Jiraporn Jit on Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders.

COMMENT Good paper. 0 saosaoka

Prashanthi Vemuri

Mayo Clinic and Foundation
Rochester, United States

Lowering ApoE Brings Down Amyloid in Mice

RESEARCH NEWS 2011-12-21 Research News Apolipoprotein E4 (ApoE4), the Goliath of late-onset Alzheimer's disease genes (see AlzGene top results), is an enigma. Its protein clearly plays a role in AD and could be a therapeutic target, but scientists are not sure whether they s