PAPER Rehen SK, Yung YC, McCreight MP, Kaushal D, Yang AH, Almeida BS, Kingsbury MA, Cabral KM, McConnell MJ, Anliker B, Fontanoz M, Chun J

Constitutional aneuploidy in the normal human brain.

J Neurosci. 2005 Mar 2;25(9):2176-80. PubMed: 15745943

PAPER Johnson GV, Seubert P, Cox TM, Motter R, Brown JP, Galasko D

The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments.

J Neurochem. 1997 Jan;68(1):430-3. PubMed: 8978756

Marc Tambini on AD in the Oldest Old—What Does Aβ Have to Do With It?

COMMENT I enjoyed the airbag analogy, though I think it's hard to say that Aβ has a "protective" role. Certainly, people can live with plaques and remain cognitively intact. I think we need to clearly understand the function of full-length APP. Pre

PAPER Mori K, Arzberger T, Grässer FA, Gijselinck I, May S, Rentzsch K, Weng SM, Schludi MH, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C, Edbauer D

Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.

Acta Neuropathol. 2013 Oct 17; PubMed: 24132570

PAPER Mizielinska S, Lashley T, Norona FE, Clayton EL, Ridler CE, Fratta P, Isaacs AM

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Acta Neuropathol. 2013 Oct 30; PubMed: 24170096

PAPER Chung DW, Rudnicki DD, Yu L, Margolis RL

A natural antisense transcript at the Huntington's disease repeat locus regulates HTT expression.

Hum Mol Genet. 2011 Sep 1;20(17):3467-77. PubMed: 21672921

PAPER Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS, Hagerman RJ, Tassone F, Tapscott SJ, Filippova GN

An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals.

Hum Mol Genet. 2007 Dec 15;16(24):3174-87. PubMed: 17921506

Sanjay Pimplikar on Shutdown Grabs Headlines, but Sequestration Does Real Damage

COMMENT There are really no easy answers to the current dreadful funding situation and I applaud Mike Vitek’s suggestion of eliminating indirect costs as a potential way to make more dollars available for actual research. However, even he must realize that this i

Markus Kummer on Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient-Derived Neurons.

COMMENT Chung and colleagues elegantly demonstrate in this article how a familiar Parkinson mutation, the A53T variant of α-synuclein, causes nitrosative stress that affects the secretory transport of several neuronal proteins in iPS-derived neurons. This phenome

Douglas Galasko on Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer's Disease.

COMMENT This study confirms the observation we made years ago that the majority of tau in cerebrospinal fluid (CSF) is not full-length, but consists of fragments that are detectable using N-terminal antibodies. This new study makes use of an extensive panel of we

Roger Dodd

University of Cambridge
Cambridge

Alzforum Readers, Vote for $50,000 Award Winner

COMMUNITY NEWS 2013-11-01 Community News When it comes to Alzheimer’s disease, women bear the brunt of the risk. That fact spurred this year’s Geoffrey Beene NeuroDiscovery Challenge, an annual contest to encourage promising research that addresses a particular topic in neuroscien

Sense, Antisense: C9ORF72 Makes Both Forms of RNA, Peptides

RESEARCH NEWS 2013-11-01 Research News The puzzle of neurodegenerative disease caused by expansions in the C9ORF72 gene just grew more intricate. In four recent papers, researchers report that the repeat is transcribed and translated not only in the forward, sense direction, but

Brain a Jumble of Genetically Distinct Neurons?

RESEARCH NEWS 2013-11-01 Research News The word mosaic conjures up images of colorful tiles artfully arranged. For neurobiologists, the word may invoke the genetic hodgepodge that is the human brain. In the November 1 Science, researchers led by Fred Gage at the Salk Institute fo

Tau Biomarkers—More Informative Fragments in Spinal Fluid?

RESEARCH NEWS 2013-11-01 Research News With continued focus on fluid biomarkers for Alzheimer’s disease and emerging evidence that pathological tau travels between neurons, scientists are coming up with better ways to measure tau in cerebrospinal fluid (CSF). In the October 7 PLo