PAPER Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa M
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PAPER Brettschneider J, Del Tredici K, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, Kwong L, Lee EB, Elman L, McCluskey L, Fang L, Feldengut S, Ludolph AC, Lee VM, Braak H, Trojanowski JQ
Stages of pTDP-43 pathology in amyotrophic lateral sclerosis.
Ann Neurol. 2013 Jul;74(1):20-38. PubMed: 23686809MAPT P364S
MUTATIONS MAPT 44096076 GRCh37/hg19 C T Exon 12 Point, Missense Coding Reduced ability to promote microtubule assembly compared with wild-type tau and an increased rate of tau aggregation; Increased chromosomal instability and copy-number variations in lymphocytes
MAPT G366R
MUTATIONS MAPT 44096082 GRCh37/hg19 G A Exon 12 Point, Missense Coding Reduced ability to promote microtubule assembly compared with wild-type tau, but similar aggregation kinetics; Increased chromosomal instability and copy number variations in lymphocytes and fib
Nicholas Kanaan on ‘Godfather of Tau’ Skip Binder Dies at 63
COMMENT Very simply, Skip was a wonderful person, mentor, scientist, and friend. His generosity seemed to know no bounds, and his exceptional intelligence and rigorous research earned him respect and admiration from his colleagues and friends across the globe. He
The Four Stages of TDP-43 Proteinopathy
CONFERENCE COVERAGE 2013-11-22 Conference Coverage As misfolded proteins corrupt their natively folded counterparts, many neurodegenerative diseases spread from one part of the brain to the next in a predictable fashion. To take a crack at formally categorizing this sequence for the ne
Are New Cognitive Tests Ready For Preclinical Trials?
CONFERENCE COVERAGE 2013-11-22 Conference Coverage With Alzheimer’s trials starting to recruit cognitively normal and mildly impaired people at risk for Alzheimer’s dementia, researchers need tests that can detect subtle cognitive changes. Many groups are developing cognitive composite
PAPER Kim S, Park JM, Moon J, Choi HJ
Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress.
Exp Neurol. 2014 Feb;252:63-74. Epub 2013 Nov 16 PubMed: 24252179PAPER Dimant H, Kalia SK, Kalia LV, Zhu LN, Kibuuka L, Ebrahimi-Fakhari D, McFarland NR, Fan Z, Hyman BT, McLean PJ
Direct detection of alpha synuclein oligomers in vivo.
Acta Neuropathol Commun. 2013 May 9;1(1):6. PubMed: 24252244PAPER Mann DM, Rollinson S, Robinson A, Bennion Callister J, Thompson JC, Snowden JS, Gendron T, Petrucelli L, Masuda-Suzukake M, Hasegawa M, Davidson Y, Pickering-Brown S
Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.
Acta Neuropathol Commun. 2013 Oct 14;1(1):68. PubMed: 24252525PAPER Bernal-Pacheco O, Oyama G, Briton A, Singleton AB, Fernandez HH, Rodriguez RL, Malaty IA, Okun MS
A Novel DYT-5 Mutation with Phenotypic Variability within a Colombian Family.
Tremor Other Hyperkinet Mov (N Y). 2013;3 Epub 2013 Oct 10 PubMed: 24255805PAPER Kawaguchi-Niida M, Yamamoto T, Kato Y, Inose Y, Shibata N
MCP-1/CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS.
Acta Neuropathol Commun. 2013 Jun 4;1(1):21. PubMed: 24252211PAPER Li XZ, Zhang SN, Wang KX, Liu HY, Yang ZM, Liu SM, Lu F
Neuroprotective effects of extract of Acanthopanax senticosus harms on SH-SY5Y cells overexpressing wild-type or A53T mutant α-synuclein.
Phytomedicine. 2014 Apr 15;21(5):704-11. Epub 2013 Nov 16 PubMed: 24252343PAPER Kuijpers M, van Dis V, Haasdijk ED, Harterink M, Vocking K, Post JA, Scheper W, Hoogenraad CC, Jaarsma D
Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment.
Acta Neuropathol Commun. 2013 Jun 12;1(1):24. PubMed: 24252306PAPER Dias V, Junn E, Mouradian MM
The role of oxidative stress in Parkinson's disease.
J Parkinsons Dis. 2013;3(4):461-91. PubMed: 24252804Current Filters
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