PAPER Nixon RA, Lee JH, Wolfe D
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Seiko Ikezu on Two Paths for TREM2-Positive Microglia: DAM or Senescence?
COMMENT In this article, Schwartz’s group elegantly demonstrated the presence of senescent microglia in aged mice and in the 5xFAD Alzheimer’s disease (AD) mouse model by using CyTOF. While expressing senescent proteins, such as CD38, senescent microglia surprisi
Postdoctoral Associate
JOB 2024-04-28 Employer University of Pittsburgh Principal Investigator Thomas Karikari Description The Biofluid Biomarker Laboratory, directed by Thomas Karikari in the School of Medicine, Department of Psychiatry, invites applications for postdoctoral associates to be
Research Fellow in Molecular Neuropathology
JOB 2024-04-28 Employer Indiana University School of Medicine Principal Investigator Bernardino Ghetti Description The Dementia Laboratory, co-led by Bernardino Ghetti and Kathy L. Newell of the Indiana University School of Medicine Department of Pathology and Laborator
APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
RESEARCH NEWS 2024-04-27 Research News C-terminal fragments of amyloid precursor protein have been blamed for endolysosomal dysfunction in Alzheimer’s disease. Now, scientists led by Wim Annaert at KU Leuven, Belgium, claim that’s because these fragments disrupt calcium flux. In
Jessica Young on APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
COMMENT In this elegant study by Bretou et al., new mechanistic evidence is provided for APP-mediated endolysosomal dysfunction in AD. Altered lysosomal Ca2+ levels due to APP-CTF accumulation at the lysosome side of lysosome-ER contact sites appear to be the dri
Ralph Nixon, Ju-Hyun Lee on APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
COMMENT Bretou and the Annaert group report observations on the interplay of calcium, APP-βC-terminal fragments (βCTF), and the endolysosomal system using mainly a mouse embryonic fibroblast cell line that was CRISPR-edited to delete both presenilin 1 and PSEN2.
Rik van der Kant on APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
COMMENT I think this is a beautiful paper with a lot of high-quality cell biology on the role of APP and γ-secretase on endolysosomal function. The authors convincingly show that the inhibition, or loss, of γ-secretase activity results in endolysosomal dysfunctio
Rick Livesey on APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
COMMENT Previous studies in human neurons have established that mutations in APP and PSEN1 causal for AD result in endolysosomal and autophagy dysfunction as a consequence of reduced turnover of C-terminal fragments of APP (APP-CTFs), and that this is probably a
Stefan Lichtenthaler on APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
COMMENT This study provides exciting mechanistic insights into how APP CTFs, and not Aβ, may contribute to the lysosomal dysfunction in Alzheimer’s disease. This cell biological study is comprehensive, carefully conducted, convincing, and in good agreement with p
Gunnar Gouras on APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
COMMENT I really enjoy reading papers from the Annaert lab because of their high level of cell biology, which is so needed for our field to better understand the cellular mechanisms underlying AD. This paper by Bretou et al. is a tour de force with diverse and el
PAPER Burgoyne T, Patel S, Eden ER
Calcium signaling at ER membrane contact sites.
Biochim Biophys Acta. 2015 Sep;1853(9):2012-7. Epub 2015 Feb 4 PubMed: 25662816Small Business Transition Grant for New Entrepreneurs (R41/R42 Clinical Trial Required) (PAR-24-134)
GRANT Friday, April 26, 2024- 4:30pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-24-134.html 06 Apr 2027
Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed) (PA-24-191)
GRANT Friday, April 26, 2024- 4:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PA-24-191.html 08 May 2027
Mentored Quantitative Research Development Award (Parent K25 Independent Basic Experimental Studies with Humans Required) (PA-24-192)
GRANT Friday, April 26, 2024- 4:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PA-24-192.html 08 May 2027
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