PAPER Tanne JH

Alzheimer's researchers face trial for scientific fraud and defrauding US government.

BMJ. 2012;344:e3608. PubMed.

Megan KK

United States

Jens Kuhn on Increased Cerebral Metabolism After 1 Year of Deep Brain Stimulation in Alzheimer Disease.

COMMENT Since the end of the 1980s, deep-brain stimulation (DBS) has substantially expanded the therapeutically possibilities of treating Parkinson’s disease (1). DBS refers to a complex neuromodulative procedure, which implies the stereotactical implantation of

Katja Hardenacke

Germany

Jens Kuhn

University of Cologne
Germany

NACC News: Building a Frontotemporal Database, and More

COMMUNITY NEWS 2012-05-24 Community News Alzheimer’s disease research has received a huge boost in recent years through the development of large pooled datasets. Alas, the same cannot be said for frontotemporal lobar degenerations (FTLD). FTLDs are as devastating as Alzheimer’s, e

William Brooks on NIH Director Announces $100M Prevention Trial of Genentech Antibody

COMMENT This is welcome news. Families with dominantly inherited Alzheimer’s disease have largely been unable to participate in trials; symptomatic family members are sometimes too young for trials which may exclude people with younger onset age; they may live fa

John Ringman on NIH Director Announces $100M Prevention Trial of Genentech Antibody

COMMENT The public release of news regarding funding for, and the naming of the drug to be used in, an upcoming prevention study in persons at risk for PSEN1 mutations is a long-awaited landmark. We’ve been performing observational studies of persons with or at r

PAPER Agosta F, Canu E, Valsasina P, Riva N, Prelle A, Comi G, Filippi M

Divergent brain network connectivity in amyotrophic lateral sclerosis.

Neurobiol Aging. 2012 May 17; PubMed.

PAPER Smith KR, Damiano J, Franceschetti S, Carpenter S, Canafoglia L, Morbin M, Rossi G, Pareyson D, Mole SE, Staropoli JF, Sims KB, Lewis J, Lin WL, Dickson DW, Dahl HH, Bahlo M, Berkovic SF

Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage.

Am J Hum Genet. 2012 Jun 8;90(6):1102-7. PubMed.

PAPER Ritz B, Rhodes SL, Bordelon Y, Bronstein J

α-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease.

PLoS One. 2012;7(5):e36199. PubMed.

PAPER Herzig MC, Bidinosti M, Schweizer T, Hafner T, Stemmelen C, Weiss A, Danner S, Vidotto N, Stauffer D, Barske C, Mayer F, Schmid P, Rovelli G, van der Putten PH, Shimshek DR

High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.

PLoS One. 2012;7(5):e36581. PubMed.

PAPER Yuan CY, Lee YJ, Hsu GS

Aluminum overload increases oxidative stress in four functional brain areas of neonatal rats.

J Biomed Sci. 2012;19(1):51. PubMed.

PAPER Lopes MW, Soares FM, de Mello N, Nunes JC, de Cordova FM, Walz R, Leal RB

Time-Dependent Modulation of Mitogen Activated Protein Kinases and AKT in Rat Hippocampus and Cortex in the Pilocarpine Model of Epilepsy.

Neurochem Res. 2012 Sep;37(9):1868-78. PubMed.

PAPER Naismith SL, Norrie LM, Mowszowski L, Hickie IB

The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features.

Prog Neurobiol. 2012 Jul;98(1):99-143. PubMed.