Natural History-Cum-Trials Initiative, Grants to Boost Down’s Research

RESEARCH NEWS 2012-12-13 Research News Down’s syndrome (DS) and Alzheimer’s disease (AD) are inextricably linked. People with Down’s carry a third copy of the amyloid precursor protein (APP) gene on their triplicated chromosome 21, and are almost certain to develop amyloid pathol

PAPER Wang X, Shen Y, Chen W

Progress in frontotemporal dementia research.

Am J Alzheimers Dis Other Demen. 2013 Feb;28(1):15-23. PubMed: 23221030

PAPER Larner AJ

Can the Frontal Assessment Battery (FAB) help in the diagnosis of behavioural variant frontotemporal dementia? A pragmatic study.

Int J Geriatr Psychiatry. 2013 Jan;28(1):106-7. PubMed: 23225696

PAPER Smith WW, Schreck CF, Hashem N, Soltani S, Nath A, Rhoades E, O'Hern CS

Molecular simulations of the fluctuating conformational dynamics of intrinsically disordered proteins.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Oct;86(4 Pt 1):041910. PubMed: 23214618

PAPER Piltonen M, Savolainen M, Patrikainen S, Baekelandt V, Myöhänen TT, Männistö PT

Comparison of motor performance, brain biochemistry and histology of two A30P α-synuclein transgenic mouse strains.

Neuroscience. 2013 Feb 12;231:157-68. PubMed: 23219665

PAPER Paleologou KE, El-Agnaf OM

α-Synuclein Aggregation and Modulating Factors.

Subcell Biochem. 2012;65:109-64. PubMed: 23225002

PAPER Gan L, Vargas MR, Johnson DA, Johnson JA

Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.

J Neurosci. 2012 Dec 5;32(49):17775-87. PubMed: 23223297

PAPER Tricoire L, Vitalis T

Neuronal nitric oxide synthase expressing neurons: a journey from birth to neuronal circuits.

Front Neural Circuits. 2012;6:82. PubMed: 23227003

PAPER Sikorska B, Liberski PP

Human prion diseases: from Kuru to variant Creutzfeldt-Jakob disease.

Subcell Biochem. 2012;65:457-96. PubMed: 23225013

PAPER Roos PM, Vesterberg O, Syversen T, Flaten TP, Nordberg M

Metal concentrations in cerebrospinal fluid and blood plasma from patients with amyotrophic lateral sclerosis.

Biol Trace Elem Res. 2013 Feb;151(2):159-70. PubMed: 23225075

PAPER Avihingsanon A, Maek-A-Nantawat W, Sithinamsuwan P, Ananworanich J, Suksawak S, Saysombut N, Charoenporn W, Phanuphak P, Valcour V

Impaired neurocognitive function among HIV-infected Thais on stable antiretroviral therapy for more than 7 years.

J Int AIDS Soc. 2012;15(6):18129. PubMed: 23217833

PAPER Musarò A

Understanding ALS: new therapeutic approaches.

FEBS J. 2012 Dec 6; PubMed: 23217177

PAPER Sugaya K

Modeling the Polyglutamine Aggregation Pathway in Huntington's Disease: From Basic Studies to Clinical Applications.

Subcell Biochem. 2012;65:353-88. PubMed: 23225011

PAPER Kalia LV, Kalia SK, McLean PJ, Lozano AM, Lang AE

α-Synuclein oligomers and clinical implications for Parkinson disease.

Ann Neurol. 2012 Aug 28; PubMed: 23225525

PAPER An LN, Yue Y, Guo WZ, Miao YL, Mi WD, Zhang H, Lei ZL, Han SJ, Dong L

Surgical trauma induces iron accumulation and oxidative stress in a rodent model of postoperative cognitive dysfunction.

Biol Trace Elem Res. 2013 Feb;151(2):277-83. PubMed: 23229539