PAPER Congdon EE, Gu J, Sait HB, Sigurdsson EM
SEARCH RESULTS
332189 RESULTS
PAPER Lattanzio F, Carboni L, Carretta D, Rimondini R, Candeletti S, Romualdi P
Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice.
Neuroscience. 2014 Jan 3;256:360-9. Epub 2013 Oct 23 PubMed: 24161275PAPER Sams-Dodd F
Target-based drug discovery: is something wrong?
Drug Discov Today. 2005 Jan 15;10(2):139-47. PubMed: 15718163PAPER Swinney DC
Phenotypic vs. target-based drug discovery for first-in-class medicines.
Clin Pharmacol Ther. 2013 Apr;93(4):299-301. PubMed: 23511784Juan Pablo Palavicini
UT Health SASan Antonio, United States
PAPER Swinney DC, Anthony J
How were new medicines discovered?
Nat Rev Drug Discov. 2011 Jul;10(7):507-19. PubMed: 21701501Martin Sanders on Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson's Disease.
COMMENT The studies reported with low-dose bexarotene are promising and consistent with findings in preclinical Parkinson's studies we have reported at various meetings using IRX4204, a more potent and selective RXR agonist than bexarotene. IRX4204 is a clin
Renuka Ranjan on The role of APP and BACE1 trafficking in APP processing and amyloid-β generation.
COMMENT I think that BACE1 antagonists should act in combination with some drug that boosts or maintains the muscle spindle structure so that BACE inhibition does not hamper motor coordination. 0 renukaranjantiwari
Steve Barger on Surprise Save: Excitability Protects Neurons from Lou Gehrig’s
COMMENT This confirms a hypothesis that I invoked to explain the results of a study in which I was involved, that examined the role of D-serine in ALS. D-Ser is a co-agonist at the NMDA-R "glycine" site, and is likely to be the most important agonist in
PAPER Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MW, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuiness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Deniz Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F, European Alzheimer's Disease Initiative (EADI), Genetic and Environmental Risk in Alzheimer's Disease, Alzheimer's Disease Genetic Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology, Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannefelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltuenen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P, Wang J, Uitterlinden AG, Rivadeneira F, Koudstgaal PJ, Longstreth WT Jr, Becker JT, Kuller LH, Lumley T, Rice K, Garcia M, Aspelund T, Marksteiner JJ, Dal-Bianco P, Töglhofer AM, Freudenberger P, Ransmayr G, Benke T, Toeglhofer AM, Bressler J, Breteler MM, Fornage M, Hernández I, Rosende Roca M, Ana Mauleón M, Alegrat M, Ramírez-Lorca R, González-Perez A, Chapman J, Stretton A, Morgan A, Kehoe PG, Medway C, Lord J, Turton J, Hooper NM, Vardy E, Warren JD, Schott JM, Uphill J, Ryan N, Rossor M, Ben-Shlomo Y, Makrina D, Gkatzima O, Lupton M, Koutroumani M, Avramidou D, Germanou A, Jessen F, Riedel-Heller S, Dichgans M, Heun R, Kölsch H, Schürmann B, Herold C, Lacour A, Drichel D, Hoffman P, Kornhuber J, Gu W, Feulner T, van den Bussche H, Lawlor B, Lynch A, Mann D, Smith AD, Warden D, Wilcock G, Heuser I, Wiltgang J, Frölich L, Hüll M, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Singleton AB, Guerreiro R, Jöckel KH, Klopp N, Wichmann HE, Dickson DW, Graff-Radford NR, Ma L, Bisceglio G, Fisher E, Warner N, Pickering-Brown S
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
Nat Genet. 2013 Dec;45(12):1452-8. Epub 2013 Oct 27 PubMed: 24162737Second Study Confirms Antisense Oligonucleotides Bust RNA Aggregates
RESEARCH NEWS 2013-10-29 Research News Scientists have been chasing C9ORF72 with antisense oligonucleotides ever since the gene and its transcript were linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. On October 16, one research group claimed some succes
Yeast May Point the Way to Effective Parkinson’s Drugs
RESEARCH NEWS 2013-10-29 Research News For more than a decade, scientists have known that α-synuclein plays an important role in Parkinson’s disease, but they are still unsure how the protein influences pathology. Reporting in two papers in the October 24 Science, scientists led
PAPER Michaelis EK
Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging.
Prog Neurobiol. 1998 Mar;54(4):369-415. PubMed: 9522394PAPER Cummings JL, Kaufer D
Neuropsychiatric aspects of Alzheimer's disease: the cholinergic hypothesis revisited.
Neurology. 1996 Oct;47(4):876-83. PubMed: 8857712Carla d'Avanzo
MGH harvard medical schoolUnited States
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