Taos: New Neurons in New Mexico—Highlights from Keystone

CONFERENCE COVERAGE 2011-02-17 Conference Coverage “I want to be a ballet dancer,” said Billy Elliot in the movie of the same name. His father had other ideas: “Lads do football…or boxing…or wrestling!” Perhaps Billy just wanted to protect his brain from contact sports? And what about

Taos: Disease, Drug Development, and Adult Neurogenesis

RESEARCH NEWS 2011-02-17 Research News It is now firmly established that neurogenesis takes place in two small regions of the mammalian adult brain: the subventricular zone just underneath the brain ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Rese

Praveen Kumar Sriram

India

PAPER Kim EJ, Park YE, Kim DS, Ahn BY, Kim HS, Chang YH, Kim SJ, Kim HJ, Lee HW, Seeley WW, Kim S

Inclusion body myopathy with Paget disease of bone and frontotemporal dementia linked to VCP p.Arg155Cys in a Korean family.

Arch Neurol. 2011 Jun;68(6):787-96. PubMed: 21320982

Stress Granules and Neurodegenerative Disease—What’s the Scoop?

WEBINAR 2011-02-17 The formation of cytoplasmic inclusions called stress granules is one of nature’s many ways of coping with adverse situations. It appears that these inclusions sequester non-essential messenger RNAs, allowing cells to focus on making proteins, such as cha

PAPER Dudzik CG, Walter ED, Millhauser GL

Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's disease.

Biochemistry. 2011 Mar 22;50(11):1771-7. PubMed: 21319811

PAPER Meloni G, Vašák M

Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3.

Free Radic Biol Med. 2011 Jun 1;50(11):1471-9. PubMed: 21320589

PAPER Münch C, O'brien J, Bertolotti A

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3548-53. PubMed: 21321227

PAPER Ren R, Zhang Y, Li B, Wu Y

Effect of β-amyloid (25-35) on mitochondrial function and expression of mitochondrial permeability transition pore proteins in rat hippocampal neurons.

J Cell Biochem. 2011 May;112(5):1450-7. PubMed: 21321998

PAPER Choi JM, Hong JH, Chae MJ, Ngyuen PH, Kang HS, Ma HI, Kim YJ

Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease.

Neurosci Lett. 2011 Apr 15;493(3):97-101. PubMed: 21320571

PAPER Halliday GM, Stevens CH

Glia: initiators and progressors of pathology in Parkinson's disease.

Mov Disord. 2011 Jan;26(1):6-17. PubMed: 21322014

PAPER Wu W, Xing L, Zhou B, Lin Z

Active protein aggregates induced by terminally attached self-assembling peptide ELK16 in Escherichia coli.

Microb Cell Fact. 2011;10:9. PubMed: 21320350

PAPER Zheng J, Liu C, Sawaya MR, Vadla B, Khan S, Woods RJ, Eisenberg D, Goux WJ, Nowick JS

Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide.

J Am Chem Soc. 2011 Mar 9;133(9):3144-57. PubMed: 21319744

PAPER Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA

Targets for AD treatment: conflicting messages from γ-secretase inhibitors.

J Neurochem. 2011 May;117(3):359-74. PubMed: 21320126

PAPER Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB, Huryn DM

Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies.

Curr Top Med Chem. 2011;11(3):317-30. PubMed: 21320060