332040 RESULTS
COMMENT Perspective on the findings and their implications. Age-related Alzheimer’s disease (AD) is a neurodegenerative disorder with a complex pattern of genetic and environmental factors contributing to its pathogenesis. One gene stands, however, central for ri
COMMENT I think this paper is helpful in putting some biomarker and neuropathology heft behind the growing consensus in the field that E4 homozygosity, in European ancestry individuals at least, is all but deterministic for the development of Alzheimer’s disease
COMMENT The authors of this manuscript analyzed, together, data from a number of previously published studies and comment that: “Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from a
COMMENT We commend Fortea and colleagues for their analyses examining biomarker and clinical changes in a large number of cognitively impaired and unimpaired persons from NACC, Alfa plus, A4 trial, OASIS, ADNI, and WRAP. In general, the results from their retrosp
Icahn School of Medicine at Mount Sinai
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