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Perivascular Macrophages: The Real Amyloid Clean-Up Crew?

RESEARCH NEWS 2011-08-06 Research News Immune cells have been shown to play a role in clearing Aβ from the brain, but it's not clear exactly which subset of cells is responsible. Is it the phagocytes already present in the brain—the microglia—or are new cells recruited from

PAPER Bowers S, Truong AP, Jeffrey Neitz R, Hom RK, Sealy JM, Probst GD, Quincy D, Peterson B, Chan W, Galemmo RA, Konradi AW, Sham HL, Tóth G, Pan H, Lin M, Yao N, Artis DR, Zhang H, Chen L, Dryer M, Samant B, Zmolek W, Wong K, Lorentzen C, Goldbach E, Tonn G, Quinn KP, Sauer JM, Wright S, Powell K, Ruslim L, Ren Z, Bard F, Yednock TA, Griswold-Prenner I

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5521-7. PubMed: 21813278

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