331397 RESULTS
COMMENT This paper beautifully shows that by using a unique method of AAV-mediated gene delivery via the choroid plexus and ependyma, relatively small increases in expression of human ApoE4 are achieved that increase Aβ deposition and toxicity, while ApoE2 has th
COMMENT In this interesting study, the authors demonstrate that the ApoE4 gene variant increases amyloid plaque load, promotes synaptic loss and neuritic dystrophy in close proximity to the plaques, and delays Aβ clearance. In contrast, ApoE2 expression decreases
COMMENT Although the association of ApoE with AD risk and age of onset is indisputable, whether ApoE is a tractable therapeutic target remains an open question. Brad Hyman’s group has recently published a paper that adds considerable strength to the therapeutic p
COMMENT In this elegantly performed study, Hudry and colleagues addressed a few important gaps in the literature on ApoE and its links to amyloid pathology and Alzheimer’s disease. By using a still-unexplored strategy of adding the three different human ApoE isof
PAPER El-Azab MF, Baldowski BR, Mysona BA, Shanab AY, Mohamed IN, Abdelsaid MA, Matragoon S, Bollinger KE, Saul A, El-Remessy AB
PAPER Vantaggiato C, Clementi E, Bassi MT
PAPER Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS
PAPER Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM
CONFERENCE COVERAGE SERIES Are New Cognitive Tests Ready For Preclinical Trials? Do Tau Tracers Track Cognitive Decline in Disease? Growth Factor Therapy: Safe in Phase 1, Awaiting Efficacy Data Clinical Trials on Alzheimer’s Disease 2013
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CONFERENCE COVERAGE 2013-11-29 Conference Coverage The later stages of Alzheimer’s disease are characterized by massive loss of neurons, and researchers are looking at ways to boost molecular support systems in the hope of preserving some of those cells. At the Sixth Clinical Trials Co
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PAPER Wood H
PAPER Lagarde J, Valabrègue R, Corvol JC, Pineau F, Le Ber I, Vidailhet M, Dubois B, Levy R
PAPER Newman AJ, Selkoe D, Dettmer U
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